MR Imaging-based Biomarker Development in Hemorrhagic Stroke Patients Including Brain Iron Quantification, Diffusion Tensor Imaging, and Phenomenon of Ultra-early Erythrolysis.

Sravanthi Koduri, Aditya Pandey, Neeraj Chaudhary, Guohua Xi, Thomas L Chenevert, Momodou G Bah, Ehsan Dowlati, Max Fleigner, Leanne Y Lin, Jonathan Troost, Richard Keep

Journal: Neuroimaging clinics of North America 2024;34(2):215-224

PMID: 38604706

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Abstract

This review article discusses the role of MR imaging-based biomarkers in understanding and managing hemorrhagic strokes, focusing on intracerebral hemorrhage (ICH) and aneurysmal subarachnoid hemorrhage. ICH is a severe type of stroke with high mortality and morbidity rates, primarily caused by the rupture of small blood vessels in the brain, resulting in hematoma formation. MR imaging-based biomarkers, including brain iron quantification, ultra-early erythrolysis detection, and diffusion tensor imaging, offer valuable insights for hemorrhagic stroke management. These biomarkers could improve early diagnosis, risk stratification, treatment monitoring, and patient outcomes in the future, revolutionizing our approach to hemorrhagic strokes.

Address: Michigan State University College of Human Medicine, Lansing, MI, USA.; Department of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA.; Oakland University, William Beaumont School of Medicine, Detroit, MI, USA.; Department of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA; Department of Radiology, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Radiology, University of Michigan, Ann Arbor, MI 48109, USA.; Michigan Institute for Clinical and Health Research, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Neurosurgery, University of Michigan, Ann Arbor, MI 48109, USA; Department of Radiology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Otorhinolaryngology, University of Michigan, Ann Arbor, MI 48109, USA. Electronic address: [email protected].

DOI: 10.1016/j.nic.2024.01.001

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MeSH Terms: Humans, Diffusion Tensor Imaging, Hemorrhagic Stroke, Iron, Brain, Cerebral Hemorrhage, Stroke, Biomarkers, Magnetic Resonance Imaging