Intestinal Re-Transplantation.

Elizabeth A Marcus, Ronald W Busuttil, Douglas G Farmer, Robert S Venick, Carolyn P Smullin, Suzanne V McDiarmid, Hasan Yersiz

Journal: Gastroenterology clinics of North America 2024;53(3):453-459

PMID: 39068006

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Abstract

The history of intestinal transplantation can be traced back to the turn of the twentieth century. Although advancements have been made, the intestine still presents a greater challenge to transplantation than does that of other solid organs, experiencing higher rates of graft rejection and lower long-term survival. Increasingly, intestinal re-transplantation (re-ITx) is seen as a viable option and is now the fourth most common indication for ITx. Changes to immunosuppression protocols, technical modifications, and infectious disease monitoring have contributed to improved outcomes. The authors review the literature on re-ITx in regard to the history, management considerations, and future directions.

Published by Elsevier Inc.

Address: Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.; Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.; Division of Liver and Pancreas Transplantation, Department of Surgery, The Dumont UCLA Transplant Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.; Division of Liver and Pancreas Transplantation, Department of Surgery, The Dumont UCLA Transplant Center, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA. Electronic address: [email protected].

DOI: 10.1016/j.gtc.2024.01.004

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MeSH Terms: Humans, Reoperation, Intestines, Graft Rejection, Immunosuppressive Agents, Organ Transplantation, Graft Survival