Synthetic peptides in the diagnosis of HIV infection.

Maria Claudia Alcaro, Elisa Peroni, Paolo Rovero, Anna Maria Papini

Journal: Current protein & peptide science 2004;4(4):285-90

PMID: 14529535

Abstract

Peptide-based enzyme-linked immunosorbent assays have been found to be enough sensitive and specific for the diagnosis of human immunodeficiency virus specific antibodies in acquired immunodeficiency syndrome patients. This review provides an overview of the most important peptides developed for use as synthetic antigens in immunodiagnosis of HIV-infected patients. In particular, many studies have been devoted to discriminate between the two retroviruses HIV-1 and HIV-2, as well as different subtypes.

Address: Laboratory of Peptide Chemistry & Immunology, Dipartimento di Chimica Organica "Ugo Schiff", Università di Firenze, Polo Scientifico, I-50019 Sesto Fiorentino (FI), Italy.

DOI: 10.2174/1389203033487117

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MeSH Terms: AIDS Serodiagnosis, Amino Acid Sequence, Enzyme-Linked Immunosorbent Assay, Epitopes, HIV Infections, HIV-1, HIV-2, Human T-lymphotropic virus 1, Human T-lymphotropic virus 2, Humans, Molecular Sequence Data, Peptides, Recombinant Proteins, Sensitivity and Specificity