An Overview of Cannabidiol as a Multifunctional Drug: Pharmacokinetics and Cellular Effects.

Ariel H Polizio, Stefano Toldo, Antonio Abbate, Michele Golino, Nadia Martinez Naya, Jazmin Kelly, Giuliana Corna, Eleonora Mezzaroma

Journal: Molecules (Basel, Switzerland) 2024;29(2):

PMID: 38257386

Abstract

Cannabidiol (CBD), a non-psychoactive compound derived from Cannabis Sativa, has garnered increasing attention for its diverse therapeutic potential. This comprehensive review delves into the complex pharmacokinetics of CBD, including factors such as bioavailability, distribution, safety profile, and dosage recommendations, which contribute to the compound's pharmacological profile. CBD's role as a pharmacological inhibitor is explored, encompassing interactions with the endocannabinoid system and ion channels. The compound's anti-inflammatory effects, influencing the Interferon-beta and NF-κB, position it as a versatile candidate for immune system regulation and interventions in inflammatory processes. The historical context of Cannabis Sativa's use for recreational and medicinal purposes adds depth to the discussion, emphasizing CBD's emergence as a pivotal phytocannabinoid. As research continues, CBD's integration into clinical practice holds promise for revolutionizing treatment approaches and enhancing patient outcomes. The evolution in CBD research encourages ongoing exploration, offering the prospect of unlocking new therapeutic utility.

Address: Robert M. Berne Cardiovascular Research Center, Division of Cardiovascular Medicine, School of Medicine, University of Virginia, Charlottesville, VA 22903, USA.; Interventional Cardiology Department, Hospital Italiano de Buenos Aires, Buenos Aires 1199, Argentina.; Pauley Heart Center, Virginia Commonwealth University, Richmond, VA 23220, USA.; Department of Medicine and Surgery, University of Insubria, 2110 Varese, Italy.; Robert M. Berne Cardiovascular Research Center, Division of Cardiovascular Medicine, School of Medicine, University of Virginia, Charlottesville, VA 22903, USA.; Pauley Heart Center, Virginia Commonwealth University, Richmond, VA 23220, USA.; School of Pharmacy, Virginia Commonwealth University, Richmond, VA 23220, USA.
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