Fatty Acid Metabolism Disruptions: A Subtle yet Critical Factor in Adverse Pregnancy Outcomes.

Feng Xie, Ming-Qing Li, Tao Zhang, Ting Peng, Xiao-Yan Cao, Meng-Ying Li, Chang-Xiang Shao, Jia-Lu Shi

Journal: International journal of biological sciences 2024;20(15):6018-6037

PMID: 39664564

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Abstract

The establishment and maintenance of pregnancy encompass a series of complex and high-energy-consuming physiological processes, resulting in a significant energy demand. Fatty acids, one of the most essential nutrients, play a crucial role in energy supply via oxidation and perform critical biological functions such as anti-inflammatory and anti-oxidant effects, which substantially impact human health. Disordered fatty acid metabolism can cause anomalies in fetal growth and development, as well as a range of pregnancy problems, which can influence the health of both the mother and the fetus. In this review, we innovatively explore the relationship between fatty acid metabolism abnormalities and pregnancy complications, emphasizing the potential of dietary interventions with polyunsaturated fatty acids in improving pregnancy outcomes. These findings provide important evidence for clinical interventions and enhance the understanding and practical application of health management during pregnancy.

Address: Department of Reproductive Immunology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, People's Republic of China.; Laboratory for Reproductive Immunology, Hospital of Obstetrics and Gynecology, Shanghai Medical School, Fudan University, Shanghai 200080, People's Republic of China.; Laboratory for Reproductive Immunology, Hospital of Obstetrics and Gynecology, Shanghai Medical School, Fudan University, Shanghai 200080, People's Republic of China.; Department of Obstetrics and Gynecology, Shanghai Changning Maternity & Infant Health Hospital, East China Normal University, Shanghai 200051, People's Republic of China.; Assisted Reproductive Technology Unit, Department of Obstetrics and Gynecology, Faculty of Medicine, Chinese University of Hong Kong, Hong Kong, People's Republic of China.; Department of Reproductive Immunology, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200030, People's Republic of China.; Shanghai Key Laboratory of Embryo Original Diseases, Shanghai 200030, People's Republic of China.

DOI: 10.7150/ijbs.103404

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MeSH Terms: Pregnancy, Female, Humans, Fatty Acids, Pregnancy Outcome, Pregnancy Complications