Good clinical practice recommendations for the diagnosis and treatment of functional dyspepsia: An expert review from the Asociación Mexicana de Gastroenterología.

E C Morel-Cerda, R I Carmona-Sánchez, L R Valdovinos-García, M Morales-Arámbula, G Vázquez-Elizondo, M A Valdovinos-Díaz, M V Bielsa-Fernández, O Gómez-Escudero, A Noble-Lugo, E Coss-Adame, J M Remes-Troche, M C Rodríguez-Leal, K García-Zermeño, P Gómez-Castaños, S Solórzano-Olmos, O E Trujillo-Benavides

Journal: Revista de gastroenterologia de Mexico (English) 2025;90(2):227-251

PMID: 40399175

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Abstract

INTRODUCTION AND AIMS

Functional dyspepsia (FD) is a highly prevalent condition characterized by upper gastrointestinal symptoms with no apparent organic cause. It is a complex and multifactorial disease that frequently overlaps with other disorders of gut-brain interaction. It is recurrent, has a variable therapeutic response, and affects patient quality of life. Our aim was to formulate good practice recommendations for the management of FD through a consensus review of the disease, updating and complementing the 2017 consensus on dyspepsia from the Asociación Mexicana de Gastroenterología (AMG).

METHODS

Sixteen experts summoned by the AMG carried out a literature review (2017-2024) and formulated good clinical practice recommendations for the diagnosis and treatment of FD. They were discussed until reaching a consensus, and the most recent evidence on the theme was evaluated, utilizing the GRADE system.

RESULTS

Twenty-three good clinical practice recommendations for the management of FD were developed that addressed the following aspects: (1) definition, pathophysiology, and epidemiology; (2) diagnosis; (3) nonpharmacologic treatment; (4) Helicobacter pylori eradication; (5) antisecretory and anti-acid therapy; and (6) prokinetics and neuromodulators.

CONCLUSIONS

FD is one of the most frequent gastrointestinal conditions seen in daily practice. We present good clinical practice recommendations for the specific management of this disorder, taking into account the most recent advances that complement and update the consensus on dyspepsia published by the AMG in 2017.

Address: Práctica Privada, San Luis Potosí, San Luis Potosí, Mexico. Electronic address: [email protected].; GastroAlliance/ONCARE Centro de Enfermedades Digestivas, Monterrey, Nuevo León, Mexico.; Hospital Ángeles Valle Oriente, Monterrey, Nuevo León, Mexico.; Clínica de Gastroenterología y Motilidad Gastrointestinal, Hospital Ángeles Puebla, Puebla, Mexico.; Práctica Privada, Guadalajara, Jalisco, Mexico.; Departamento de Gastroenterología y Laboratorio de Motilidad Gastrointestinal, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.; Centro Integral de Gastroenterología y Motilidad Avanzada, Boca del Río Veracruz, Veracruz, Mexico.; Centro de Investigación y Docencia en Ciencias de la Salud de la Universidad Autónoma de Sinaloa, Culiacán, Sinaloa, Mexico.; Servicio de Gastroenterología y Endoscopía, Hospital Country 2000, Guadalajara, Jalisco, Mexico.; Departamento de Gastroenterología, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico.; Servicio de Gastroenterología y Departamento de Enseñanza e Investigación, Hospital Español de México, Mexico City, Mexico.; Laboratorio de Fisiología Digestiva y Motilidad Gastrointestinal, Instituto de Investigaciones Médico-Biológicas, Universidad Veracruzana, Veracruz, Veracruz, Mexico.; Práctica privada, Hospital México-Americano, Guadalajara, Jalisco, Mexico.; Hospital General de Zona 42, Instituto Mexicano del Seguro Social, Puerto Vallarta, Jalisco, Mexico.; Servicio de Gastroenterología, Hospital Médica Sur, Mexico City, Mexico.; Cirugía Experimental del Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Escuela Superior de Medicina, Instituto Politécnico Nacional, Mexico City, Mexico.

DOI: 10.1016/j.rgmxen.2025.05.001

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Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S2255...

Medical:

https://medlineplus.gov/indigestion.html

MeSH Terms: Dyspepsia, Humans, Helicobacter Infections, Mexico, Consensus