Myocardial infarction with nonobstructive coronary arteries (MINOCA): a narrative review.

Yaru Zhang, Cheng Shen, Pengfei Yang, Yong Cao, Shuang Zhang, Xiaorong Yin, Haoran Zhu

Journal: European journal of medical research 2025;30(1):443

PMID: 40452049

Free Full Text on BioMed Central View on PubMed

Abstract

Myocardial infarction with nonobstructive coronary arteries (MINOCA) refers to myocardial infarction cases with less than 50% narrowing of coronary arteries, accounting for about 2% to 10% of acute myocardial infarction cases, mainly in females. While MINOCA typically has a more favorable prognosis compared to obstructive CAD, the negative effects of MINOCA must not be overlooked. By amalgamating contemporary research on MINOCA, this study systematically delineates its progression, encompassing plaque lesions, coronary artery dissection, coronary microvascular spasm, thromboembolism, among others, various diagnostic techniques (such as coronary angiography, intravascular ultrasound, etc.) plus therapeutic approaches (such as statins, calcium channel blockers, antiplatelet medications, etc.). After pinpointing MINOCA's origin via supplementary correlative assessments, tailored treatment approaches become essential. In addition, this review also emphasizes current experiments that could offer fresh perspectives on treating MINOCA.

Address: Department of Clinical Medicine, Jining Medical University, Jining, Shandong, China.; Department of Cardiology, Affiliated Hospital of Jining Medical University, Jining, Shandong, China.; Shandong Provincial Key Medical and Health Discipline of Cardiology, Affiliated Hospital of Jining Medical University, Jining, Shandong, China.; Shandong Provincial Key Medical and Health Laboratory of Diagnosis and Treatment of Cardiovascular Diseases, Affiliated Hospital of Jining Medical University, Jining, Shandong, China.; Jining Key Laboratory of Precise Therapeutic Research of Coronary Intervention, Jining, Shandong, China.; Department of Cardiology, Affiliated Hospital of Jining Medical University, Jining, Shandong, China. [email protected].; Shandong Provincial Key Medical and Health Discipline of Cardiology, Affiliated Hospital of Jining Medical University, Jining, Shandong, China. [email protected].; Shandong Provincial Key Medical and Health Laboratory of Diagnosis and Treatment of Cardiovascular Diseases, Affiliated Hospital of Jining Medical University, Jining, Shandong, China. [email protected].; Jining Key Laboratory of Precise Therapeutic Research of Coronary Intervention, Jining, Shandong, China. [email protected].

DOI: 10.1186/s40001-025-02703-3

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https://assays.cancer.gov/CPTAC-466

MeSH Terms: Humans, Coronary Vessels, MINOCA, Coronary Angiography, Myocardial Infarction, Prognosis