tRNA modification in plant pathogenic fungi: roles, mechanisms, and implications for pathogenicity.

Ziwei Lv, Hong Hu, Yinan Li, Zhipeng Zhou, Xiao-Lin Chen

Journal: The New phytologist 2025;247(2):527-532

PMID: 40452131

Abstract

Transfer RNA (tRNA) modifications refer to the chemical alterations that occur on tRNA molecules, which are essential for their structure, stability, and function. These modifications have been shown to play crucial roles in diverse biological processes across different organisms. Recent studies have highlighted that specific tRNA modifications are directly linked to virulence traits and infection processes in plant pathogenic fungi. This review aims to explore their roles in fungal biology and pathogenicity, summarize the current understanding of the molecular mechanisms of tRNA modification in plant pathogenic fungi, and discuss the potential implications for developing novel antifungal strategies.

Address: National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China.; College of Life Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China.; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China.; College of Life Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China.; National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China.; Provincial Key Laboratory of Plant Pathology of Hubei Province, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, 430070, China.

DOI: 10.1111/nph.70276

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https://doi.org/10.1111/nph.70276

MeSH Terms: RNA, Transfer, Fungi, Plant Diseases, Plants, Virulence, RNA Processing, Post-Transcriptional