Functions and Regulation of the Outer Membrane Protein TolC in Species.

Yue Gong, Xin Tian, Chunxia Liu, Young Ran Kim

Journal: ACS infectious diseases 2025;11(7):1756-1764

PMID: 40498510

Full Text on American Chemical Society View on PubMed

Abstract

TolC, a multifunctional outer membrane protein, creates a continuous conduit that extrudes substrates from the bacterial periplasm and the outer leaflet of the inner membrane to the external environment. TolC of species functions as an outer membrane protein of multiple exporters, and is involved in antibiotic efflux, regulation and export of virulence factors, iron homeostasis, and survival under various extreme environments, thereby playing an indispensable role in the pathogenesis of species. This review recapitulates the current knowledge about the functions and regulators of TolC homologous proteins in species.

Address: Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, PR China.; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Chonnam National University, Gwangju 61186, Republic of Korea.; Department of Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, PR China.; Henan Key Laboratory of Precision Clinical Pharmacy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.; College of Pharmacy and Research Institute of Pharmaceutical Sciences, Chonnam National University, Gwangju 61186, Republic of Korea.

DOI: 10.1021/acsinfecdis.4c01058

Link outs

Subscription / membership required

Full Text Sources:

https://doi.org/10.1021/acsinfecdis.4c01058

MeSH Terms: Bacterial Outer Membrane Proteins, Vibrio, Gene Expression Regulation, Bacterial, Virulence Factors