Advances in Single-Photon Emission Computed Tomography: Hardware, Software, and Myocardial Flow Reserve.

Anahita Tavoosi, Roger Glenn Wells, Gary R Small, Yoshito Kadoya, Terrence D Ruddy

Journal: Heart failure clinics 2025;21(3):327-337

PMID: 40506147

Full Text on Elsevier Science View on PubMed

Abstract

The clinical presentation of coronary artery disease (CAD) has changed during the last 20 years with less ischemia on stress testing and more nonobstructive CAD on coronary angiography. Single-photon emission computed tomography (SPECT) myocardial perfusion imaging should include the measurement of myocardial flow reserve and assessment of coronary calcium for the diagnosis of nonobstructive CAD and coronary microvascular disease. SPECT/CT systems provide reliable attenuation correction for better specificity and low-dose CT for coronary calcium evaluation. SPECT MFR measurement is accurate, well validated, and repeatable.

Address: Division of Cardiology, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario K1Y 4W7, Canada. Electronic address: [email protected].; Division of Cardiology, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario K1Y 4W7, Canada.

DOI: 10.1016/j.hfc.2025.01.018

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MeSH Terms: Humans, Tomography, Emission-Computed, Single-Photon, Coronary Artery Disease, Fractional Flow Reserve, Myocardial, Myocardial Perfusion Imaging, Software, Coronary Angiography, Coronary Circulation