Widefield OCT angiography.

Yukun Guo, An-Lun Wu, Tristan T Hormel, Yifan Jian, Thomas S Hwang, Steven T Bailey, John C Morrison, Xiang Wei, Yali Jia, David Huang, J Peter Campbell, Guangru B Liang, Shuibin Ni

Journal: Progress in retinal and eye research 2025;107():101378

PMID: 40517946

Full Text on Elsevier Science View on PubMed

Abstract

Optical coherence tomography angiography (OCTA) is a volumetric, non-invasive, high-resolution vascular imaging modality capable of acquiring highly detailed visualizations of retinal microvasculature. It has become an important tool for diagnosis and prognosis in prevalent diseases and pathologies such as diabetic retinopathy, retinopathy of prematurity, and vein occlusions, as well as more rare conditions, including inherited retinal dystrophies. It is also useful for measuring treatment response and assessing which patients would benefit from treatment. Unlike dye-based angiography, OCTA eliminates risks such as anaphylaxis. It also often outperforms fundus photography in feature detection. However, conventional OCTA imaging has been limited by its small field of view, which restricts simultaneous visualization of the posterior pole and peripheral retina, causing single images to potentially miss widely spaced critical biomarkers and pathological features. Recent technological advances in widefield OCTA have addressed this limitation, extending the field of view to the mid-periphery and beyond. This breakthrough enhances the simultaneous detection of macular and peripheral retinal pathology and significantly broadens OCTA's diagnostic and research applications. This review explores the technical innovations enabling widefield OCTA and highlights its clinical utility across various conditions, emphasizing its growing importance as a powerful tool in ophthalmic practice and research.

Address: Casey Eye Institute, Oregon Health and Science University, Portland, OR, USA; Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR, USA. Electronic address: [email protected].; Casey Eye Institute, Oregon Health and Science University, Portland, OR, USA.; Casey Eye Institute, Oregon Health and Science University, Portland, OR, USA; Department of Biomedical Engineering, Oregon Health and Science University, Portland, OR, USA.

DOI: 10.1016/j.preteyeres.2025.101378

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MeSH Terms: Humans, Tomography, Optical Coherence, Fluorescein Angiography, Retinal Vessels, Retinal Diseases