Recent advances in metallophore research uncover functions in quorum sensing, antimicrobial activity, and lanthanide acquisition.

Ghazal Kamyabi, Erica L Debley, Elizabeth M Nolan

Journal: Current opinion in chemical biology 2025;87():102604

PMID: 40540790

Full Text on Elsevier Science View on PubMed

Abstract

Metallophores are metal-chelating secondary metabolites that bacteria, fungi, and other organisms produce to acquire essential metal nutrients from their environment. This review highlights some recent discoveries in the field: the role of yersiniabactin in quorum sensing, the capacity of aspergillomarasmine A to inhibit bacterial Ni uptake, and the identification of methylolanthanin, a novel metallophore that enables bacterial lanthanide acquisition.

Address: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. Electronic address: [email protected].

DOI: 10.1016/j.cbpa.2025.102604

Link outs

Subscription / membership required

Full Text Sources:

https://linkinghub.elsevier.com/retrieve/pii/S1367...

MeSH Terms: Quorum Sensing, Lanthanoid Series Elements, Bacteria, Anti-Infective Agents