Expert Opinion on Management Advancements in Sarcopenia: From Muscle Wasting to Recovery.

Naresh Shetty, Nimitha Pinto, Sameer Muchhala, Ram Prabhoo, Vinod Gupta, Abhilasha Jain, H K Ganesh, Suneet Kumar Verma, Nitin Kapoor, Sanjay Kalra, Rashi Agrawal, Lakshmi Nagendra, Sambit Das, A K Das, Sourabh Sharma, Atul Dhingra, Narendra Kotwal, Arun Kumar Singh, Hanjabam Barun Sharma

Journal: The Journal of the Association of Physicians of India 2025;73(6):50-60

PMID: 40553592

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Abstract

Sarcopenia, an age-related condition marked by the decline of skeletal muscle mass, strength, and function, often leads to loss of function, disability, and diminished quality of life (QoL) in the elderly population. Despite its growing prevalence, sarcopenia is frequently underdiagnosed and inadequately managed. Timely detection and appropriate interventions are crucial to slowing disease progression and minimizing associated risks. As standardized guidelines and individualized management plans are necessary to improve clinical outcomes, this consensus paper presents expert insights into advancements in sarcopenia management, including diagnostic criteria and therapeutic interventions, and the need for personalized screening tools for Indian demographics. Furthermore, experts emphasized the importance of a multimodal approach, integrating resistance exercise, nutritional optimization, and emerging pharmacological therapies for effective sarcopenia treatment. The role of anabolic agents such as nandrolone decanoate in muscle preservation is explored, alongside considerations for patient selection and safety. This paper underscores the importance of a patient-centered approach, which addresses both functional recovery and overall well-being of individuals at risk or diagnosed with sarcopenia.

Address: Treasurer, International Society of Endocrinology (ISE); Vice President, South Asian Obesity Forum (SOF); Bharti Hospital, Karnal, Haryana, India, Orcid: https://orcid.org/0000-0003-1308-121X.; Dean Academic, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth, Puducherry, India.; Director, Department of Endocrinology, Paras Hospitals, Panchkula, Haryana, India.; Head of Department and Associate Professor, Department of Endocrinology, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India, Corresponding Author.; Consultant, Department of Endocrinology, Kokilaben Dhirubhai Ambani Hospital, Navi Mumbai, Maharashtra, India.; Consultant Endocrinologist, Maithri Clinic, Mangalore, Karnataka, India.; Professor and Head, Department of Endocrinology, Kalinga Institute of Medical Sciences, KIIT DU, Bhubaneswar, Odisha, India.; Director, Department of Endocrinology, Metro Heart Institute with Multispecialty, Faridabad, Haryana, India.; Head of Department, Professor, and Consultant, Department of Endocrinology, Diabetes and Metabolism, Christian Medical College, Vellore, Tamil Nadu, India; Non-communicable Disease Unit, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia, Orcid: https://orcid.org/0000-0002-9520-2072.; Associate Professor, Department of Medicine, Dr SS Tantia Medical College Hospital & Research Centre, Sri Ganganagar, Rajasthan, India.; Consultant, Department of Endocrinology, Jain Hospital, Kaithal, Haryana, India.; Assistant Professor, Department of Nephrology, VMMC & Safdarjung Hospital, New Delhi, India, Orcid: https://orcid.org/0000-0003-2513-5131.; Senior Medical Officer, Deen Dayal Upadhyay Zonal Hospital, Shimla, Himachal Pradesh, India.; Consultant, Department of Internal Medicine, Alchemist Hospital, Panchkula, Haryana; Sparsh Clinic, Zirakpur, Punjab, India.; Assistant Professor, Department of Physiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India.; Head, Department of Orthopedics, Mukund Hospital; Wadia Hospital, Mumbai, Maharashtra, India.; Chief Executive Officer, Department of Orthopedics, Akash Institute of Medical Sciences & Research Centre, Bengaluru, Karnataka, India.; General Manager, Medical Affairs, Zydus Healthcare Limited, Mumbai, Maharashtra, India.; Manager, Medical Affairs, Zydus Healthcare Limited, Mumbai, Maharashtra, India, Orcid: https://orcid.org/0009-0003-5016-9103.

DOI: 10.59556/japi.73.1031

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Research Materials:

https://antibodies.cancer.gov/detail/CPTC-HLA-B-1

MeSH Terms: Humans, Sarcopenia, Quality of Life, Anabolic Agents, Aged