Diagnosis and Treatment of HFE-Linked Hemochromatosis.

Paul C Adams

Journal: Advances in experimental medicine and biology 2025;1480():119-130

PMID: 40603788

Abstract

Genetic variants for hemochromatosis have been identified in human fossils that are over 4000 years old in Northern Ireland. Iron overload can lead to life-threatening complications, including liver fibrosis, cirrhosis, and hepatocellular carcinoma. In this review, the emphasis is on developments in the diagnosis and treatment of C282Y-linked hemochromatosis. There is a need for earlier diagnosis leading to earlier treatment to prevent morbidity and mortality.

Address: Western University, London, ON, Canada. [email protected].

DOI: 10.1007/978-3-031-92033-2_9

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https://dx.doi.org/10.1007/978-3-031-92033-2_9

MeSH Terms: Humans, Hemochromatosis, Hemochromatosis Protein