Mean Corpuscular Volume (MCV) and Mean Platelet Volume (MPV) as early diagnostic markers for preeclampsia, gestational diabetes, and anemia: a systematic review of clinical evidence and mechanisms.

Naif Taleb Ali

Journal: BMC pregnancy and childbirth 2025;25(1):722

PMID: 40610949

Free Full Text on BioMed Central View on PubMed

Abstract

BACKGROUND

This systematic review (2018-2023) evaluates the diagnostic accuracy of MCV and MPV in pregnancy-related disorders.

OBJECTIVES

Evaluate diagnostic accuracy of MCV/MPV for pregnancy complications.

METHODS

PRISMA 2020 review of 36 studies (2018-2023) using automated analyzers.

RESULTS

- MPV > 10.2 fL predicts preeclampsia (78% sensitivity, AUC 0.81). - MCV < 80 fL indicates iron-deficiency anemia (85% specificity). - MPV > 9.8 fL associates with gestational diabetes (OR 2.3, 95% CI 1.8-3.0). - $0.20/test cost advantage.

CONCLUSION

These low-cost markers could enhance early detection in resource-limited settings. These hematological markers are associated with up to 60% reduction in diagnostic costs when compared to conventional testing methods, making them viable for LMICs.

Address: Department of Laboratory Sciences, Radfan University College, Lahej University, Alhouta, Yemen. [email protected].; Department of Laboratory Sciences, University of Sciences and Technology, Aden, Yemen. [email protected].

DOI: 10.1186/s12884-025-07802-x

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MeSH Terms: Humans, Pregnancy, Female, Pre-Eclampsia, Mean Platelet Volume, Diabetes, Gestational, Erythrocyte Indices, Biomarkers, Early Diagnosis, Anemia, Sensitivity and Specificity, Anemia, Iron-Deficiency