The 5C model: Clinical approach to peripheral neuropathy.

Atul Dhingra, Sanjay Kalra, Nitin Kapoor, Suneet Kumar Verma

Journal: JPMA. The Journal of the Pakistan Medical Association 2025;75(6):1000-1001

PMID: 40698484

Abstract

Peripheral neuropathy is a common condition which is often missed in primary care. The 5C model simplifies the clinical approach to peripheral neuropathy, listing steps of history taking, physical examination and investigations. One begins by eliciting complaints and concerns, and "classifying by the calendar". Comorbid and contributory diseases, concomitant medications and contacted toxins, are then identified. The complications of neuropathy, and the corrective measures undertaken so far, are explored. This is followed by a physical examination, and supplemented by investigations. Once the diagnosis is confirmed, comprehensive management, guided by the LEMON mnemonic, which lists the various facets of neuropathy care, has to be planned.

Address: Department of Endocrinology, Bharti Hospital, Karnal, India; University Center for Research & Development, Chandigarh University, Mohali, India.; Department of Endocrinology, Dr SS Tantai Medical College Hospital & Research Centre, Sriganganagar, India.; Department of Medicine, Alchemist Hospital, Panchkula India; Sparsh Clinic, Panchkula, India.; Department of Endocrinology, Diabetes and Metabolism, Christian Medical College, Vellore, India; Non communicable disease unit, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
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