Aging and Herbal Interventions: Mechanistic Insights and Therapeutic Potential.

Abija James, Anand Kumar, Rupak Nagraik, Arun Kumar, Deepak Kumar, Divyesh Suvedi, Sonika Kalia, Sapna Koul, Henok Gulilat

Journal: Journal of cosmetic dermatology 2025;24(7):e70335

PMID: 40702898

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Abstract

BACKGROUND

Skin aging is a multifactorial process influenced by an individual's genetic predisposition, lifestyle choices, and environmental factors. This process leads to epidermal thinning, a reduction in collagen and elastin levels, and a decrease in skin suppleness. While aging cannot be entirely prevented, its effects can be mitigated through the application of appropriate skincare products.

AIM

This review examines the potential of natural herbal extracts in anti-aging skincare formulations, focusing on their bioactivity and safety, which aligns with current consumer trends favoring natural, organic, and eco-friendly products.

METHODS

A systematic literature review was performed with the help of PubMed and ScienceDirect to thoroughly examine articles between 2000 and 2025. The review made use of key phrases including "skin aging," "herbal extracts," and "anti-aging cosmetics."

RESULTS

Bioactive compounds such as polyphenols, flavonoids, and essential oils, present in plants, confer multiple benefits for the skin, including moisturizing properties, barrier repair agents, antioxidants, sunscreens, and anti-inflammatory effects. These compounds also protect and rejuvenate the skin through distinct anti-aging mechanisms.

CONCLUSION

The use of herbal extracts in combination with nano-formulations enhances the efficacy of skincare regimens while improving stability. The integration of plant-based resources, when combined with a balanced diet and a healthy lifestyle, can significantly enhance holistic and effective anti-aging skincare.

Address: Faculty of Applied Sciences and Biotechnology, Shoolini University, Solan, Himachal Pradesh, India.; Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Shoolini University, Solan, Himachal Pradesh, India.; Department of Biotechnology, School of Applied and Life Sciences, Uttaranchal University, Dehradun, India.; Polish Academy of Sciences, Institute of Biochemistry and Biophysics, Warsaw, Poland.; Faculty of Applied Sciences and Biotechnology, Shoolini University, Solan, Himachal Pradesh, India.; Department of Biotechnology, Graphic Era (Deemed to Be University), Dehradun, India.; Department of Biomedical Sciences, Institute of Health, Jimma University, Jimma, Oromia, Ethiopia.

DOI: 10.1111/jocd.70335

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MeSH Terms: Humans, Skin Aging, Plant Extracts, Rejuvenation, Phytotherapy, Skin, Cosmetics, Skin Care, Antioxidants