Comprehensive review of steroid metabolism in Comamonas testosteroni TA441 with insights from other aerobic steroid-degrading bacteria.

Masae Horinouchi, Toshiaki Hayashi

Journal: Advances in applied microbiology 2025;131():1-20

PMID: 40818839

Full Text on Elsevier Science View on PubMed

Abstract

Comamonas testosteroni TA441 is a model bacterium for aerobic steroid degradation. This review summarizes its steroid degradation pathways, including the genetic organization and enzymatic mechanisms involved in C17-side chain degradation, A,B-ring cleavage, and β-oxidation of B,C,D-rings. Comparative insights from other aerobic steroid-degrading bacteria highlight the evolutionary conservation of key enzymes. Understanding these pathways provides crucial insights into microbial steroid metabolism and its environmental significance.

Address: Environmental Molecular Biology Laboratory, RIKEN, Saitama, Japan; Surface and Interface Science Laboratory, RIKEN, Saitama, Japan.; Environmental Molecular Biology Laboratory, RIKEN, Saitama, Japan.

DOI: 10.1016/bs.aambs.2025.06.001

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MeSH Terms: Comamonas testosteroni, Steroids, Metabolic Networks and Pathways, Aerobiosis