The Liver in Hematologic Malignancies: Lymphoma, Leukemia, and Myeloma.

Maya Gambarin-Gelwan, Natalia Zbib

Journal: Clinics in liver disease 2025;29(3):469-481

PMID: 40670033

Full Text on Elsevier Science View on PubMed

Abstract

Liver disease significantly impacts hematologic malignancies like lymphoma, leukemia, and multiple myeloma. Chronic hepatitis B and C increase risks, complicate treatment, and may lead to reactivation during chemotherapy. Bone marrow transplantation (BMT) is associated with the risk of hepatic complications. Antiviral therapy mitigates risks, improving survival. Screening and prophylactic treatment are essential for managing liver-related complications in these patients. Cirrhosis complicates the treatment of hematologic malignancies by altering drug metabolism, increasing toxicity, and heightening risks of complications. BMT further challenges liver function, with increased risk of complications like sinusoidal obstruction syndrome, requiring specialized management.

Address: Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Gastroenterology, Hepatology and Nutrition Service, Department of Medicine, Memorial Sloan Kettering Cancer Center.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Gastroenterology, Hepatology and Nutrition Service, Department of Medicine, Memorial Sloan Kettering Cancer Center; Weill Cornell College of Medicine, New York, NY, USA. Electronic address: [email protected].

DOI: 10.1016/j.cld.2025.03.009

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MeSH Terms: Humans, Multiple Myeloma, Lymphoma, Leukemia, Bone Marrow Transplantation, Liver Diseases, Hematologic Neoplasms, Hepatic Veno-Occlusive Disease, Liver Cirrhosis