Isolation and biological activity of azocine and azocane alkaloids.

Stephanie Lee, Jonathan Sperry

Journal: Bioorganic & medicinal chemistry 2022;54():116560

PMID: 34923389

Full Text on Elsevier Science View on PubMed

Abstract

Thousands of known alkaloids contain a nitrogen (N) heterocycle. While five-, six- and seven-membered N-heterocycles (ie: pyrroles, imidazoles, indoles, pyridines and azepines and their saturated variants) are common, those with an eight-membered N-heterocycle are comparatively rare. This review discusses the structure and bioactivity of alkaloids that contain an azocine (or saturated azocane) ring, and the array of sources whence they originate.

Address: School of Chemical Sciences, University of Auckland, 23 Symonds Street, Auckland, New Zealand.; School of Chemical Sciences, University of Auckland, 23 Symonds Street, Auckland, New Zealand. Electronic address: [email protected].

DOI: 10.1016/j.bmc.2021.116560

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MeSH Terms: Alkaloids, Anti-Infective Agents, Anti-Inflammatory Agents, Antimalarials, Antineoplastic Agents, Phytogenic, Azabicyclo Compounds, Azocines, Humans, Insecticides, Molecular Structure