Calcified Chondroid Mesenchymal Neoplasms.

Erica Y Kao, Eleanor Y Chen

Journal: Surgical pathology clinics 2024;17(1):77-82

PMID: 38278609

Full Text on Elsevier Science View on PubMed

Abstract

Calcified chondroid mesenchymal neoplasms (CCMN) represent a morphologic spectrum of related tumors. Historically, chondroid matrix or chondroblastoma-like features have been described in soft tissue chondroma, tenosynovial giant cell tumors (especially of the temporomandibular joint (TMJ) region), and in a subset of tophaceous pseudogout. Recently, these tumors have been found to share FN1-receptor tyrosine kinase (RTK) fusions. This review discusses the clinical, morphologic, immunohistochemical, and molecular genetic features of CCMN. The distinction from morphologic mimics is also discussed.

Address: Department of Pathology, Brooke Army Medical Center, 3551 Roger Brooke Drive, Building 3600, 4th Floor, Room 447-6, San Antonio, TX 78234, USA.; Department of Laboratory Medicine and Pathology, University of Washington, 1959 Northeast Pacific Street, Box 357705, HSB Room K072A, Seattle, WA 98195-7705, USA. Electronic address: [email protected].

DOI: 10.1016/j.path.2023.06.006

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MeSH Terms: Humans, Chondrocalcinosis, Temporomandibular Joint, Soft Tissue Neoplasms