Matthew J Burton, Lamis Al Harby, Jonathan W Kim, Jesse L Berry, Ashley Polski, Nick Astbury, Cova Bascaran, Sharon Blum, Richard Bowman, Mandeep S Sagoo, Allen Foster, Nir Gomel, Naama Keren-Froim, Shiran Madgar, Marcia Zondervan, Swathi Kaliki, Ido Didi Fabian, Andrew Stacey, Nathalie Cassoux, Xiudi Li, Arthika Chandramohan, Megan Othus, Xunda Ji, Yihua Zou, Sadia Sultana, Riffat Rashid, Sadik Taju Sherief, Thamanna Nishath, Juan Luis Garcia Leon, Rosdali Díaz Coronado, Arturo Manuel Zapata López, Tatiana L Ushakova, Vladimir G Polyakov, Soma Rani Roy, Alia Ahmad, Ashwin Reddy
Journal: The British journal of ophthalmology 2023;107(12):1818-1822
PMID: 36113955
BACKGROUND
Rates of care abandonment for retinoblastoma (RB) demonstrate significant geographical variation; however, other variables that place a patient at risk of abandoning care remain unclear. This study aims to identify the risk factors for care abandonment across a multinational set of patients.
METHODS
A prospective, observational study of 692 patients from 11 RB centres in 10 countries was conducted from 1 January 2019 to 31 December 2019. Multivariate logistic regression was used to identify risk factors associated with higher rates of care abandonment.
RESULTS
Logistic regression showed a higher risk of abandoning care based on country (high-risk countries include Bangladesh (OR=18.1), Pakistan (OR=45.5) and Peru (OR=9.23), p<0.001), female sex (OR=2.39, p=0.013) and advanced clinical stage (OR=4.22, p<0.001). Enucleation as primary treatment was not associated with a higher risk of care abandonment (OR=0.59, p=0.206).
CONCLUSION
Country, advanced disease and female sex were all associated with higher rates of abandonment. In this analysis, enucleation as the primary treatment was not associated with abandonment. Further research investigating cultural barriers can enable the building of targeted retention strategies unique to each country.
© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.
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