The effects of purslane (Portulaca oleracea) on glycemic indices: A GRADE-assessed systematic review and meta-analysis of randomized controlled trials.

Shaghayegh Abbasi, Noushin Mashatan, Elahe Farmani, Mehran Khodashenas, Vali Musazadeh, Sana Sedgh Ahrabi, Amir Hossein Moridpour, Amir Hossein Faghfouri

Journal: Phytotherapy research : PTR 2023;37(12):5529-5540

PMID: 37661794

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Abstract

Although several studies have revealed the benefits of purslane on glycemic indices, the results of some studies reject such effect. Therefore, aim of this meta-analysis of randomized controlled trials (RCTs) was to assess the effects of purslane supplementation on glycemic indices. Scientific international databases as Scopus, Web of Sciences, PubMed, Embase, and the Cochrane library were searched up to December 2022. For net changes in glycemic indices, weighted mean differences (WMDs) were calculated using random-effects models. Purslane supplementation had a statistically significant reduction in fasting blood glucose [FBG, WMD: -6.37; 95% CI: -9.34, -3.40, p < 0.001]. In addition, purslane did not significant effect on serum levels of insulin [WMD: -0.74; 95% CI: -2.58, 1.10; p = 0.430], homeostasis model assessment for insulin resistance [HOMA-IR, WMD: -0.25; 95% CI: -0.88, 0.37, p = 0.429], and QUICKI [WMD: -0.01; 95% CI: -0.01, 0.03, p = 0.317] compared with the control group. The results of our meta-analysis revealed a beneficial effect of purslane supplementation as a tool to decrease FBG levels, but not to HOMA-IR, insulin, and QUICKI levels. However, future high-quality, long-term clinical trials are needed to confirm our results.

Address: Department of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.; School of Applied Sciences, University of Brighton, Brighton, UK.; Tehran University of Medical Sciences, Tehran, Iran.; School of Medicine, Alborz University of Medical Sciences, Karaj, Iran.; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.; School of Nutrition and Food Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.; Maternal and Childhood Obesity Research Center, Urmia University of Medical Sciences, Urmia, Iran.

DOI: 10.1002/ptr.7997

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MeSH Terms: Blood Glucose, Portulaca, Glycemic Index, Randomized Controlled Trials as Topic, Insulin, Insulin Resistance, Dietary Supplements