Evaluation of the genotoxic potential of acrylamide: Arguments for the derivation of a tolerable daily intake (TDI value).

Hans-Georg Joost, Gerhard Eisenbrand, Wim Wätjen, Stefan Vieths, Pablo Steinberg, Richard Stadler, Joachim Spranger, Angelika Roth, Elke Röhrdanz, Ute Nöthlings, Doris Marko, Angela Mally, Marcel Leist, Alfonso Lampen, Dirk W Lachenmeier, Sabine E Kulling, Sabine Guth, Henry Jäger, Hans-Ulrich Humpf, Thomas Henle, Jan G Hengstler, Michael Hellwig, Volker Heinz, Dirk Haller, Tilman Grune, Bernd Epe, Barbara Engeli, Karl-Heinz Engel, Patrick Diel, Alexander T Cartus, Matthias Baum

Journal: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023;173():113632

PMID: 36708862

Abstract

This opinion of the Senate Commission on Food Safety (SKLM) of the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) presents arguments for an updated risk assessment of diet-related exposure to acrylamide (AA), based on a critical review of scientific evidence relevant to low dose exposure. The SKLM arrives at the conclusion that as long as an appropriate exposure limit for AA is not exceeded, genotoxic effects resulting in carcinogenicity are unlikely to occur. Based on the totality of the evidence, the SKLM considers it scientifically justified to derive a tolerable daily intake (TDI) as a health-based guidance value.

Copyright © 2023 The Authors. Published by Elsevier Ltd.. All rights reserved.

Address: Leibniz Research Centre for Working Environment and Human Factors (IfADo), Ardeystr. 67, 44139, Dortmund, Germany. Electronic address: [email protected].; Solenis Germany Industries GmbH, Fütingsweg 20, 47805 Krefeld, Germany. Electronic address: [email protected].; Chemservice S.A., 13, Fausermillen, 6689, Mertert, Luxembourg. Electronic address: [email protected].; Department of Molecular and Cellular Sports Medicine, Institute of Cardiovascular Research and Sports Medicine, German Sport University Cologne, Am Sportpark Müngersdorf 6, 50933, Cologne, Germany. Electronic address: [email protected].; Technical University of Munich, Maximus-von-Imhof-Forum 2, 85354, Freising, Germany. Electronic address: [email protected].; Federal Food Safety and Veterinary Office (FSVO), Risk Assessment Division, Schwarzenburgstrasse 155, 3003, Bern, Switzerland. Electronic address: [email protected].; Institute of Pharmaceutical and Biomedical Sciences, University of Mainz, Staudinger Weg 5, 55128, Mainz, Germany. Electronic address: [email protected].; Department of Molecular Toxicology, German Institute of Human Nutrition (DIfE), Arthur-Scheunert-Allee 114-116, 14558, Nuthetal, Germany. Electronic address: [email protected].; ZIEL - Institute for Food & Health, Technical University of Munich, 85354, Freising, Germany; Technical University of Munich, Gregor-Mendel-Str. 2, 85354, Freising, Germany. Electronic address: [email protected].; German Institute of Food Technologies (DIL), Prof.-von-Klitzing-Str. 7, 49610, Quakenbrück, Germany. Electronic address: [email protected].; Technische Universität Dresden, Bergstraße 66, 01062, Dresden, Germany. Electronic address: [email protected].; Leibniz Research Centre for Working Environment and Human Factors (IfADo), Ardeystr. 67, 44139, Dortmund, Germany. Electronic address: [email protected].; Department of Food Chemistry, TU Dresden, Bergstrasse 66, 01062, Dresden, Germany. Electronic address: [email protected].; Institute of Food Chemistry, Westfälische Wilhelms-Universität Münster, Corrensstraße 45, 48149, Münster, Germany. Electronic address: [email protected].; Institute of Food Technology, University of Natural Resources and Life Sciences (BOKU), Muthgasse 18, 1190, Vienna, Austria. Electronic address: [email protected].; Department of Experimental Diabetology, German Institute of Human Nutrition (DIfE), Arthur-Scheunert-Allee 114-116, 14558, Nuthetal, Germany. Electronic address: [email protected].; Department of Safety and Quality of Fruit and Vegetables, Max Rubner-Institut, Federal Research Institute of Nutrition and Food, Haid-und-Neu-Straße 9, 76131, Karlsruhe, Germany. Electronic address: [email protected].; Chemisches und Veterinäruntersuchungsamt Karlsruhe, Weißenburger Str. 3, 76187, Karlsruhe, Germany. Electronic address: [email protected].; University of Veterinary Medicine Hannover, Institute for Food Quality and Food Safety, Bischofsholer Damm 15, 30173, Hannover, Germany. Electronic address: [email protected].; In Vitro Toxicology and Biomedicine, Department Inaugurated By the Doerenkamp-Zbinden Foundation, University of Konstanz, Box 657, 78457, Konstanz, Germany. Electronic address: [email protected].; Department of Toxicology, University of Würzburg, Versbacher Str. 9, 97078, Würzburg, Germany. Electronic address: [email protected].; Department of Food Chemistry and Toxicology, Faculty of Chemistry, University of Vienna, Währinger Straße 38, 1090, Vienna, Austria. Electronic address: [email protected].; Department of Nutrition and Food Sciences, Nutritional Epidemiology, Rheinische Friedrich-Wilhelms University Bonn, Friedrich-Hirzebruch-Allee 7, 53115, Bonn, Germany. Electronic address: [email protected].; Unit Reproductive and Genetic Toxicology, Federal Institute for Drugs and Medical Devices (BfArM), Kurt-Georg-Kiesinger Allee 3, 53175, Bonn, Germany. Electronic address: [email protected].; Leibniz Research Centre for Working Environment and Human Factors (IfADo), Ardeystr. 67, 44139, Dortmund, Germany. Electronic address: [email protected].; Department of Endocrinology and Metabolic Medicine, Campus Benjamin Franklin, Charité University Medicine, Hindenburgdamm 30, 12200, Berlin, Germany. Electronic address: [email protected].; Institute of Food Safety and Analytical Sciences, Nestlé Research Centre, Route du Jorat 57, 1000, Lausanne, 26, Switzerland. Electronic address: [email protected].; Max Rubner-Institut, Federal Research Institute of Nutrition and Food, Haid-und-Neu-Str. 9, 76131, Karlsruhe, Germany. Electronic address: [email protected].; Paul-Ehrlich-Institut, Paul-Ehrlich-Straße 51-59, 63225, Langen, Germany. Electronic address: [email protected].; Institut für Agrar- und Ernährungswissenschaften, Martin-Luther-Universität Halle-Wittenberg, Weinbergweg 22, 06120, Halle (Saale), Germany. Electronic address: [email protected].; Kühler Grund 48/1, 69126, Heidelberg, Germany. Electronic address: [email protected].
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