NMDA Inhibitors: A Potential Contrivance to Assist in Management of Alzheimer's Disease.

Sakshi Painuli, Prabhakar Semwal, Wissam Zam, Yasaman Taheri, Shahira M Ezzat, Peijun Zuo, Liping Li, Dileep Kumar, Javad Sharifi-Rad, Natália Cruz-Martins

Journal: Combinatorial chemistry & high throughput screening 2023;26(12):2099-2112

PMID: 36476432

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Abstract

Alzheimer's disease (AD) is an increasingly common neurodegenerative disease that attracts the attention of researchers and medical community in order to develop new, safe and more effective drugs. Currently available drugs could only slow the AD progression and relieve the symptoms, in addition to being linked to moderate-to-severe side effects. N-methyl D-aspartate (NMDA) receptors antagonists were reported to have the ability to block the glutamate-mediated excitotoxic activity being good therapeutic targets for several neurodegenerative diseases, including AD. Based on data obtained so far, this review provides an overview over the use of NMDA antagonists for AD treatment, starting with a key emphasis on present features and future aspects regarding the use of NMDA antagonists for AD, and lastly a key focus is also given on its use in precision medicine.

Address: Himalayan Environmental Studies and Conservation Organization (HESCO), Dehradun 248 006, Uttarakhand, India.; Department of Life Sciences, Graphic Era Deemed to be University, Dehradun-248 002, Uttarakhand, India.; Department of Analytical and Food Chemistry, Faculty of Pharmacy, Tartous University, Tartous, Syria.; Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, 11562, Egypt.; Department of Pharmacognosy, Faculty of Pharmacy, October University for Modern Science and Arts (MSA), Giza 12451, Egypt.; School of Public Health, Shantou University, Guangdong, China.; Poona College of Pharmacy, Bharati Vidyapeeth (Deemed to be University), Erandawane, Pune, 411038, Maharashtra, India.; Facultad de Medicina, Universidad del Azuay, Cuenca, Ecuador.; Faculty of Medicine, University of Porto, Alameda Prof. Hernani Monteiro, 4200-319, Porto, Portugal.; Institute for Research and Innovation in Health (i3S), University of Porto, 4200-135 Porto, Portugal.; Institute of Research and Advanced Training in Health Sciences and Technologies (CESPU), Rua Central de Gandra, 1317, 4585-116 Gandra PRD, Portugal.

DOI: 10.2174/1386207325666220428112541

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MeSH Terms: Humans, Alzheimer Disease, Neurodegenerative Diseases, Memantine, N-Methylaspartate, Receptors, N-Methyl-D-Aspartate