Nicholas Finn, Derek Tang, Paul Spin, Alexandre Mamedov, Chris Cameron, Christopher Westcott, Mohammed Siddiqui, Aksharh Thambipillai, Anne Parmentier, Robert Delage, John Storring, Mary-Margaret Keating, Thomas Nevill, Rena Buckstein, Eve St-Hilaire, Dina Khalaf, Leber Brian, Versha Banerji, Grace Christou, Heather A Leitch, April Shamy, Nancy Zhu, Michelle Geddes, Karen W L Yee, Lee Mozessohn, Lisa Chodirker
Journal: Leukemia & lymphoma 2022;63(13):3165-3174
PMID: 36095125
Patients with lower-risk (LR) myelodysplastic syndromes (MDS) with ring sideroblasts (RS) have better prognosis than those without RS, but how they fare over time is not fully understood. This study's objective was to assess the natural history of LR MDS with RS ≥5% using MDS-CAN registry individual data. Kaplan-Meier estimates and generalized linear mixed models were used to describe time-to-event outcomes and continuous outcomes, respectively. One hundred and thirty-eight patients were enrolled; median times from diagnosis to enrollment and follow-up were 6.6 and 39.6 months, respectively. Within 5 years of enrollment, 65% of patients had ≥1 red blood cell transfusion dependence episode. Within 5 years of diagnosis, 59% developed iron overload, 38% received iron chelation therapy, 14% progressed to acute myeloid leukemia, and 42% died. Patients exhibited inferior health-related quality of life trends. These first real-world data in LR MDS-RS in Canada indicate a high level of morbidity and mortality over a 5-year period. ClinicalTrials.gov Identifier: NCT02537990.
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