A natural history of lower-risk myelodysplastic syndromes with ring sideroblasts: an analysis of the MDS-CAN registry.

Nicholas Finn, Derek Tang, Paul Spin, Alexandre Mamedov, Chris Cameron, Christopher Westcott, Mohammed Siddiqui, Aksharh Thambipillai, Anne Parmentier, Robert Delage, John Storring, Mary-Margaret Keating, Thomas Nevill, Rena Buckstein, Eve St-Hilaire, Dina Khalaf, Leber Brian, Versha Banerji, Grace Christou, Heather A Leitch, April Shamy, Nancy Zhu, Michelle Geddes, Karen W L Yee, Lee Mozessohn, Lisa Chodirker

Journal: Leukemia & lymphoma 2022;63(13):3165-3174

PMID: 36095125

Abstract

Patients with lower-risk (LR) myelodysplastic syndromes (MDS) with ring sideroblasts (RS) have better prognosis than those without RS, but how they fare over time is not fully understood. This study's objective was to assess the natural history of LR MDS with RS ≥5% using MDS-CAN registry individual data. Kaplan-Meier estimates and generalized linear mixed models were used to describe time-to-event outcomes and continuous outcomes, respectively. One hundred and thirty-eight patients were enrolled; median times from diagnosis to enrollment and follow-up were 6.6 and 39.6 months, respectively. Within 5 years of enrollment, 65% of patients had ≥1 red blood cell transfusion dependence episode. Within 5 years of diagnosis, 59% developed iron overload, 38% received iron chelation therapy, 14% progressed to acute myeloid leukemia, and 42% died. Patients exhibited inferior health-related quality of life trends. These first real-world data in LR MDS-RS in Canada indicate a high level of morbidity and mortality over a 5-year period. ClinicalTrials.gov Identifier: NCT02537990.

Address: Division of Medical Oncology & Hematology, Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, ON, Canada.; Department of Medicine, University of Toronto, Toronto, ON, Canada.; Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.; Tom Baker Cancer Centre, Calgary, AB, Canada.; Division of Hematology, University of Alberta, Edmonton, AB, Canada.; Jewish General Hospital, Montréal, QC, Canada.; St. Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.; Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada.; CancerCare Manitoba, Winnipeg, MB, Canada.; Juravinski Cancer Centre, Hamilton Health Sciences, Hamilton, ON, Canada.; Centre Hospitalier Universitaire Dr. Georges-L.-Dumont, Moncton, NB, Canada.; Division of Hematology, Leukemia/Bone Marrow Transplant Program of BC, BC Cancer, University of British Columbia, Vancouver, BC, Canada.; Division of Hematology, Dalhousie University, Halifax, NS, Canada.; McGill University Health Centre, Montréal, QC, Canada.; CHU de Québec, Hôpital de l'Enfant-Jésus, Centre Universitaire d'Hématologie et d'Oncologie de Québec, Québec, QC, Canada.; Celgene Inc., a Bristol-Myers Squibb Company, Mississauga, ON, Canada.; Value and Evidence Division, Marketing & Market Access, EVERSANA™, Sydney, NS, Canada.; Bristol Myers Squibb, Princeton, NJ, USA.
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