Human colonic catabolism of dietary flavan-3-ol bioactives.

Giuseppe Di Pede, Pedro Mena, Letizia Bresciani, Tahani M Almutairi, Daniele Del Rio, Michael N Clifford, Alan Crozier

Journal: Molecular aspects of medicine 2023;89():101107

PMID: 35931563

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Abstract

Understanding the fate of ingested polyphenols is crucial in elucidating the molecular mechanisms underlying the beneficial effects of a fruit and vegetable-based diet. This review focuses on the colon microbiota-mediated transformation of the flavan-3-ols and the structurally related procyanidins found in dietary plant foods and beverages, plus the flavan-3-ol-derived theaflavins of black tea, and the post-absorption phase II metabolism of the gut microbiota catabolites. Despite significant advances in the last decade major analytical challenges remain. Strategies to address them are presented.

Address: Human Nutrition Unit, Department of Food and Drug, University of Parma, 43125, Parma, Italy.; Human Nutrition Unit, Department of Food and Drug, University of Parma, 43125, Parma, Italy; Microbiome Research Hub, University of Parma, 43124, Parma, Italy.; Department of Chemistry, King Saud University, Riyadh, 11363, Saudi Arabia.; School of Bioscience and Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XH, UK; Department of Nutrition, Dietetics, and Food, School of Clinical Sciences at Monash Health, Faculty of Medicine Nursing and Health Sciences, Monash University, Notting Hill, Victoria, 3168, Australia.; Department of Chemistry, King Saud University, Riyadh, 11363, Saudi Arabia; School of Medicine, Dentistry and Nursing, University of Glasgow, Glasgow, G12 8QQ, United Kingdom. Electronic address: [email protected].

DOI: 10.1016/j.mam.2022.101107

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MeSH Terms: Humans, Flavonoids, Polyphenols, Colon, Diet