Endoscopic Management and Surgical Considerations for Familial Adenomatous Polyposis.

Peter P Stanich, Brian Sullivan, Alex C Kim, Matthew F Kalady

Journal: Gastrointestinal endoscopy clinics of North America 2021;32(1):113-130

PMID: 34798980

Full Text on Elsevier Science View on PubMed

Abstract

Familial adenomatous polyposis (FAP) is the development of many adenomatous colorectal polyps. Colonoscopy is recommended to start at age 10 to 12 years at intervals of 1 to 2 years. Colectomy is clearly indicated for malignancy or significant colorectal symptoms. After colectomy, endoscopic surveillance is still critical. Duodenal and gastric polyposis is also found in almost all patients with FAP. Screening with upper endoscopy and ampullary visualization is recommended, generally determined by age and staging of duodenal polyposis, but guidelines are increasingly factoring in ampullary and gastric manifestations. Surgical management of malignancy or advanced upper tract manifestations is needed.

Address: Division of Gastroenterology, Hepatology & Nutrition, The Ohio State University Wexner Medical Center, 395 West 12th Avenue, Suite 200, Columbus, OH 43210, USA. Electronic address: [email protected].; Division of Gastroenterology, Duke University Medical Center, 2301 Erwin Road, Durham, NC 27710, USA. Electronic address: https://twitter.com/gi_sullivan.; Division of Surgical Oncology, The Ohio State University Wexner Medical Center, N924 Doan Hall, 410 West 10th Avenue, Columbus, OH 43210, USA. Electronic address: https://twitter.com/CRS_HIPEC.; Division of Colorectal Surgery, The Ohio State University Wexner Medical Center, 737 Doan Hall, 410 West 10th Avenue, Columbus, OH 43210, USA. Electronic address: https://twitter.com/MattKaladyMD.

DOI: 10.1016/j.giec.2021.08.007

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MeSH Terms: Adenomatous Polyposis Coli, Child, Colectomy, Duodenum, Endoscopy, Humans, Stomach Neoplasms