Colorectal Cancer Screening Recommendations and Outcomes in Lynch Syndrome.

Christine Drogan, Sonia S Kupfer

Journal: Gastrointestinal endoscopy clinics of North America 2021;32(1):59-74

PMID: 34798987

Full Text on Elsevier Science View on PubMed

Abstract

Screening for colorectal cancer (CRC) in Lynch syndrome enables early detection and likely cancer prevention. CRC screening guidelines have evolved from universal to gene-specific recommendations based on lifetime neoplasia risks. Regular screening for Lynch syndrome reduces CRC-related mortality; however, high CRC incidence during regular colonoscopy screening suggests the possibility of nonpolypoid carcinogenesis. Colonoscopy is the primary modality for screening for Lynch syndrome with mixed and emerging data on quality metrics, chromoendoscopy, artificial intelligence, and nonendoscopic modalities. Screening adherence varies across studies. In this review, we present the current state of CRC screening recommendations, outcomes, and modalities in Lynch syndrome.

Address: Section of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Chicago, Chicago, IL, USA.; Section of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Chicago, Chicago, IL, USA. Electronic address: [email protected].

DOI: 10.1016/j.giec.2021.08.001

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MeSH Terms: Artificial Intelligence, Colonoscopy, Colorectal Neoplasms, Colorectal Neoplasms, Hereditary Nonpolyposis, Early Detection of Cancer, Humans