Fecal microbiota relationships with childhood obesity: A scoping comprehensive review.

Begoña de Cuevillas, Fermín I Milagro, Josep A Tur, Mercedes Gil-Campos, Pilar de Miguel-Etayo, J Alfredo Martínez, Santiago Navas-Carretero

Journal: Obesity reviews : an official journal of the International Association for the Study of Obesity 2022;23 Suppl 1():e13394

PMID: 34913242

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Abstract

Childhood obesity is a costly burden in most regions with relevant and adverse long-term health consequences in adult life. Several studies have associated excessive body weight with a specific profile of gut microbiota. Different factors related to fecal microorganism abundance seem to contribute to childhood obesity, such as gestational weight gain, perinatal diet, antibiotic administration to the mother and/or child, birth delivery, and feeding patterns, among others. This review reports and discusses diverse factors that affect the infant intestinal microbiota with putative or possible implications on the increase of the obesity childhood rates as well as microbiota shifts associated with excessive body weight in children.

Address: Center for Nutrition Research, Department of Nutrition, Food Sciences and Physiology. School of Pharmacy and Nutrition, University of Navarra, Pamplona, Spain.; Centro de Investigación Biomédica en Red de la Fisiopatología de la Obesidad y Nutrición (CIBERobn), Instituto de Salud Carlos III, Madrid, Spain.; IdiSNA, Health Research Institute of Navarra, Pamplona, Spain.; Research Group on Community Nutrition and Oxidative Stress, University of Balearic Islands-IUNICS & IDISBA, Palma de Mallorca, Spain.; Metabolism and Investigation Unit, Reina Sofia University Hospital, Maimónides Institute of Biomedicine Research of Córdoba (IMIBIC), University of Córdoba, Córdoba, Spain.; Growth, Exercise, Nutrition and Development (GENUD) Research Group, Instituto Agroalimentario de Aragón (IA2), Universidad de Zaragoza. Instituto de Investigación Sanitaria de Aragón (IIS Aragón), Zaragoza, Spain.; Precision Nutrition Program, Research Institute on Food and Health Sciences IMDEA Food. CSIC-UAM, Madrid, Spain.

DOI: 10.1111/obr.13394

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MeSH Terms: Adult, Child, Female, Gastrointestinal Microbiome, Gestational Weight Gain, Humans, Infant, Microbiota, Pediatric Obesity, Pregnancy, Weight Gain