Gli1+ Mesenchymal Stem Cells in Bone and Teeth.

Yange Wu, Xueman Zhou, Wenxiu Yuan, Jiaqi Liu, Wenke Yang, Yufan Zhu, Chengxinyue Ye, Xin Xiong, Qinlanhui Zhang, Jin Liu, Jun Wang

Journal: Current stem cell research & therapy 2022;17(6):494-502

PMID: 34994317

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Abstract

Mesenchymal stem cells (MSCs) are remarkable and noteworthy. Identification of markers for MSCs enables the study of their niche in vivo. It has been identified that glioma-associated oncogene 1 positive (Gli1+) cells are mesenchymal stem cells supporting homeostasis and injury repair, especially in the skeletal system and teeth. This review outlines the role of Gli1+ cells as MSC subpopulation in both bones and teeth, suggesting the prospects of Gli1 an + cells in stem cell- based tissue engineering.

Address: Department of Orthodontics, State Key Laboratory of Oral Disease, National Clinical Research Center for Oral Disease, West China Hospital of Stomatology, Sichuan University, Chengdu, China.; Lab for Aging Research, National Clinical Research Center for Geriatrics, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China.

DOI: 10.2174/1574888X17666220107102911

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MeSH Terms: Humans, Mesenchymal Stem Cells, Stem Cells, Tissue Engineering, Tooth, Zinc Finger Protein GLI1