Effects of Exosomes on Major Pathways Promote Tumor Formation and Progression.

Mehmet Emin Köse, Beste Aydin, Caner Geyik, Öykü Gönül Geyik, Engin Ulukaya

Journal: Current molecular medicine 2022;22(6):491-505

PMID: 34473617

Abstract

Exosomal vesicles enclose and carry a broad range of biological molecules, such as nucleic acids, lipids, and proteins, and transfer them between cells. In cancer, cells being mentioned could be neighbors in the same tumor microenvironment communicating with each other, or they could be localized at distant sites of the body, enabling suitable conditions for metastasis. Either way, it is a concrete fact that cells under physiological or pathological conditions make crosstalk via exosomal secretion. This review looks at the relation between exosomal cargo and mechanisms of cancer through recent research.

Address: ISUMKAM Molecular Cancer Research Center, Istinye University, Istanbul, Turkey.; Cancer Biology and Pharmacology, Institute of Health Sciences, Istinye University, Istanbul, Turkey.; Medical Biochemistry Department, Faculty of Medicine, Istinye University, Istanbul, Turkey.; Nutrition and Dietetics Department, Faculty of Health Sciences, Istinye University, Istanbul, Turkey.

DOI: 10.2174/1566524021666210902113824

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MeSH Terms: Cell Communication, Exosomes, Humans, Neoplasms, Tumor Microenvironment