Protective Effects of Curcumin against Iron-induced Toxicity.

Nastaran Moinipour, Mahdi Barati, Amirhossein Sahebkar, Milad Iranshahy, Abolfazl Shakeri

Journal: Current pharmaceutical biotechnology 2022;23(8):1020-1027

PMID: 34521323

Abstract

Iron is an essential element in cellular metabolism that participates in many biochemical reactions. Nevertheless, iron overload in the body is the cause of damage in some organs including the liver, glands, brain, heart, gastrointestinal tract and lung. Iron chelation therapy could be considered an effective approach for removing excess iron. Deferoxamine, deferiprone and deferasirox are three common iron chelators in clinical practice but cause several side effects. In this context, the use of curcumin, a dietary phytochemical derived from turmeric, as a natural and safe antioxidant with iron-chelating activity may be a useful strategy for the management of iron overload. This review focuses on the deleterious effect of iron accumulation in different organs of the body as well as the therapeutic potential of curcumin against iron-induced toxicity.

Address: Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.; Depart-ment of Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.; Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran.; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.; Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.; School of Medicine, The University of Western Australia, Perth, Australia.; School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

DOI: 10.2174/1389201022666210914122846

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MeSH Terms: Curcumin, Deferiprone, Deferoxamine, Humans, Iron, Iron Chelating Agents, Iron Overload, Pyridones