Gallic Acid: A Dietary Polyphenol that Exhibits Anti-neoplastic Activities by Modulating Multiple Oncogenic Targets.

Hardeep Singh Tuli, Hiral Mistry, Ginpreet Kaur, Diwakar Aggarwal, Vivek Kumar Garg, Sonam Mittal, Mükerrem Betül Yerer, Katrin Sak, Md Asaduzzaman Khan

Journal: Anti-cancer agents in medicinal chemistry 2022;22(3):499-514

PMID: 34802408

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Abstract

Phytochemicals are being used for thousands of years to prevent dreadful malignancy. Side effects of existing allopathic treatment have also initiated intense research in the field of bioactive phytochemicals. Gallic acid, a natural polyphenolic compound, exists freely as well as in polymeric forms. The anti-cancer properties of gallic acid are indomitable by a variety of cellular pathways such as induction of programmed cell death, cell cycle apprehension, reticence of vasculature and tumor migration, and inflammation. Furthermore, gallic acid is found to show synergism with other existing chemotherapeutic drugs. Therefore, the antineoplastic role of gallic acid suggests its promising therapeutic candidature in the near future. The present review describes all these aspects of gallic acid at a single platform. In addition nanotechnology-mediated approaches are also discussed to enhance bioavailability and therapeutic efficacy.

Address: Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala, Haryana, India.; Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM's NMIMS, Mumbai 400056, Maharashtra, India.; Department of Medical Laboratory Technology, University Institute of Applied Health Sciences, Chandigarh University, Gharuan, Mohali 140413, Punjab, India.; School of Biotechnology, Jawaharlal Nehru University, New Delhi, India.; Department of Pharmacology, Faculty of Pharmacy, Erciyes University, Erciyes University Drug Application and Research Center, Kayseri, Turkey.; NGO Praeventio, Tartu 50407, Estonia.; The Research Center for Preclinical Medicine, Southwest Medical University, Luzhou 646000, China.

DOI: 10.2174/1871520621666211119085834

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MeSH Terms: Antineoplastic Agents, Phytogenic, Cell Proliferation, Gallic Acid, Humans, Neoplasms, Oncogenes, Phytochemicals