A Comprehensive Review on Pyranoindole-containing Agents.

Alessia Catalano, Domenico Iacopetta, Jessica Ceramella, Carmela Saturnino, Maria Stefania Sinicropi

Journal: Current medicinal chemistry 2022;29(21):3667-3683

PMID: 34872472

Abstract

A huge number of nitrogen-containing heterocyclic compounds are ubiquitous in natural products, pharmaceuticals, and bioactive molecules. Among these, the pyranoindole represents an important structural motif, as it constitutes the central subunit in both the biologically active natural products and therapeutic agents. Talathermophilins, notoamides, norgeamides, carneamides, and versicamides are examples of naturally occurring pyranoindoles, while the well-known etodolac and pemedolac are a tetrahydropyrano[ 3,4-b]indole deriving from synthetic procedures. Besides the well-known antiinflammatory and fibrinolytic activity, molecules comprising the pyranoindole framework have been demonstrated to exhibit various biological activities, such as antiulcer, antidepressant, analgesic, and antiproliferative. Herein, we report the most common natural and synthetic products bearing a pyranoindole nucleus, their syntheses, and biological activities.

Address: Department of Pharmacy-Drug Sciences, University of Bari "Aldo Moro", 70126 Bari, Italy.; Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, 87036 Arcavacata di Rende, Italy.; Department of Science, University of Basilicata, 85100 Potenza, Italy.

DOI: 10.2174/0929867328666211206111058

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MeSH Terms: Anti-Inflammatory Agents, Biological Products, Etodolac, Heterocyclic Compounds, Humans