Meta-analyses identify DNA methylation associated with kidney function and damage.

Address: Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany. [email protected].; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. [email protected].; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, 39216, USA.; Research Unit Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764, Neuherberg, Bavaria, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764, Neuherberg, Bavaria, Germany.; TUM School of Medicine, Technical University of Munich, Munich, Germany.; Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Framingham Heart Study, Framingham, Massachusetts, USA.; Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, US.; Department of Medicine and Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, 19104, USA.; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.; Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA.; Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.; MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.; Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.; Department of Public and Occupational Health, Amsterdam Public Health Research Institute, Amsterdam University Medical Centers, University of Amsterdam, 1105 AZ, Amsterdam, the Netherlands.; Department of Neurobiology, Care Sciences and Society (NVS), Family Medicine and Primary Care Unit, Karolinska Institutet, Huddinge, Sweden.; School of Health and Social Studies, Dalarna University, Falun, Sweden.; Population Health Sciences, German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Neurology, Faculty of Medicine, University of Bonn, Bonn, Germany.; Laboratory of Environmental Precision Health, Mailman School of Public Health, Columbia University, New York, NY, USA.; Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland.; German Cancer Research Center (DKFZ), Division of Clinical Epidemiology and Aging Research, Heidelberg, Germany.; Network Aging Research, Heidelberg University, Heidelberg, Germany.; Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.; German Cancer Consortium, German Cancer Research Center (DKFZ), Heidelberg, Germany.; Population Health Sciences, German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Institute for Medical Biometry, Informatics and Epidemiology (IMBIE), Faculty of Medicine, University of Bonn, Bonn, Germany.; Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland.; Population Health Laboratory, University of Fribourg, Fribourg, Switzerland.; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, Southall, UK.; Imperial College Healthcare NHS Trust, London, UK.; Texas Biomedical Research Institute, San Antonio, USA.; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.; Department of Medicine, University of Mississippi Medical Center, Jackson, MS, 39216, USA.; Lothian Birth Cohorts Group, Department of Psychology, The University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.; Department of Genetics, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, the Netherlands.; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Department of Chronic Diseases Epidemiology, National Center for Epidemiology, Carlos III Health Institute, Madrid, Spain.; Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, USA.; Department of Statistics and Operations Research, University of Valencia, Valencia, Spain.; Department of Nephrology and Hypertension, University of Erlangen-Nürnberg, Erlangen, Germany.; Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin Berlin, Berlin, Germany.; Institute of Human Genetics, Friedrich-Alexander-UniversitätErlangen-Nürnberg, 91054, Erlangen, Germany.; Department of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.; Centre for Genomic and Experimental Medicine, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, EH4 2XU, UK.; Department of Medicine, University of Washington, Seattle, WA, 98101, USA.; Department of Epidemiology, University of Washington, Seattle, WA, 98101, USA.; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, 98101, USA.; Brown Foundation Institute of Molecular Medicine, McGovern Medical School, Houston, TX, 77030, USA.; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.; Department of Genetics, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, the Netherlands.; Oncode Institute, Utrecht, the Netherlands.; Laboratory of Environmental Precision Health, Mailman School of Public Health, Columbia University, New York, NY, USA.; Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing, China.; German Cancer Research Center (DKFZ), Division of Clinical Epidemiology and Aging Research, Heidelberg, Germany.; Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.; Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany.; DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany.; Research Unit Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764, Neuherberg, Bavaria, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764, Neuherberg, Bavaria, Germany.; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.; Human Genetics Center, Department of Epidemiology, Human Genetics and Environmental Sciences, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA.; Department of Clinical Genetics, Amsterdam Reproduction & Development Research Institute, Amsterdam University Medical Centres, University of Amsterdam, Amsterdam, the Netherlands.; Institute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; German Center for Diabetes Research, Munich-Neuherberg, Germany.; Department of Endocrinology and Diabetology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.; Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.; Biostatistics, Fielding School of Public Health, UCLA, Los Angeles, CA, USA.; Department of Microbiology and Immunology, Faculty of Medicine and Health Technology, Tampere University, Tampere, 33014, Finland.; Framingham Heart Study, Framingham, Massachusetts, USA.; Division of Intramural Research, Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health, Imperial College London, London, UK.; Center for Life Course Health Research, Faculty of Medicine, University of Oulu, 90014, Oulu, Finland.; Biocenter Oulu, University of Oulu, Oulu, Finland.; Unit of Primary Care, Oulu University Hospital, Oulu, Finland.; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48104, USA.; Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; SYNLAB MVZ Humangenetik Mannheim, Mannheim, Germany.; Deutsches Herzzentrum München, Technische Universität München, Munich, Germany.; DZHK (German Centre for Cardiovascular Research), Partner site Munich Heart Alliance, Munich, Germany.; Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany.; Department of Cardiology, Ealing Hospital, London North West Healthcare NHS Trust, Southall, UK.; Imperial College Healthcare NHS Trust, London, UK.; National Heart and Lung Institute, Imperial College London, London, UK.; Departments of Public Health Science and Medicine, Loyola University Chicago, Maywood, IL, USA.; Edward Hines VA Medical Center, Hines, IL, USA.; Institute of Genetic Epidemiology, Medical University of Innsbruck, Innsbruck, Austria.; Department of Clinical Chemistry, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Finnish Cardiovascular Research Centre, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.; Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland.; Department of Medical Sciences, Uppsala University, Uppsala, Sweden.; Population Health Sciences, German Centre for Neurodegenerative Diseases (DZNE), Bonn, Germany.; Department of Medicine, Division of Cardiology, Duke Molecular Physiology Institute, Duke University School of Medicine, Durham, NC, USA.; Institute of Nutritional Sciences, Friedrich Schiller University Jena, Jena, Germany.; Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD) Halle-Jena-Leipzig, Jena, Germany.; Department of Human Genetics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, 90095, USA.; Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.; Competence Cluster for Nutrition and Cardiovascular Health (nutriCARD) Halle-Jena-Leipzig, Jena, Germany.; Synlab Academy, SYNLAB Holding Deutschland GmbH, Mannheim and Augsburg, Augsburg, Germany.; Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria.; Center for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.; Department of Public and Occupational Health, Amsterdam Public Health Research Institute, Amsterdam University Medical Centers, University of Amsterdam, 1105 AZ, Amsterdam, the Netherlands.; DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany.; Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.; Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, NY, USA.; Department of Neurobiology, Care Sciences and Society (NVS), Family Medicine and Primary Care Unit, Karolinska Institutet, Huddinge, Sweden.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764, Neuherberg, Bavaria, Germany.; Ludwig-Maximilians Universität München, Munich, Germany.; Institute of Human Genetics, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.; Department of Computational Health, Institute of Neurogenomics, Helmholtz Zentrum München, Munich, Germany.; Department of Medicine, University of Washington, Seattle, WA, 98101, USA.; Department of Epidemiology, University of Washington, Seattle, WA, 98101, USA.; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, 98101, USA.; Department of Health Services, University of Washington, Seattle, WA, 98101, USA.; Research centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland.; Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland.; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland.; Department of Epidemiology, University of Washington, Seattle, WA, 98101, USA.; Joslin Diabetes Center, Boston, MA, USA.; Harvard Medical School, Boston, MA, USA.; German Cancer Research Center (DKFZ), Division of Clinical Epidemiology and Aging Research, Heidelberg, Germany.; Network Aging Research, Heidelberg University, Heidelberg, Germany.; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA.; Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, USA.; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, 48104, USA.; Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, 98101, USA.; Department of Medical Sciences, Uppsala University, Uppsala, Sweden.; The George Institute for Global Health, University of New South Wales, Sydney, Australia.; Cardiovascular Health Research Unit, University of Washington, Seattle, WA, 98101, USA.; Institute for Public Health Genetics, University of Washington, Seattle, WA, USA.; Department of Chronic Diseases Epidemiology, National Center for Epidemiology, Carlos III Health Institute, Madrid, Spain.; Department of Internal Medicine, Erasmus Medical Center, Rotterdam, the Netherlands.; Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.; Department of Cardiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, Groningen, the Netherlands.; Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health, Imperial College London, London, UK.; Institute of Human Genetics, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.; Institute of Neurogenomics, Helmholtz Zentrum München, Munich, Germany.; Chair Neurogenetics, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.; Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore.; Department of Epidemiology and Biostatistics, Imperial College London, London, UK.; Research Unit Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764, Neuherberg, Bavaria, Germany.; Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, D-85764, Neuherberg, Bavaria, Germany.; DZHK (German Centre for Cardiovascular Research), Partner site Munich Heart Alliance, Munich, Germany.; Institute of Genetic Epidemiology, Faculty of Medicine and Medical Center - University of Freiburg, Freiburg, Germany.; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.; DZHK (German Centre for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany. [email protected].; Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. [email protected].; Department of Population Medicine and Lifestyle Diseases Prevention, Medical University of Bialystok, Bialystok, Poland. [email protected].