[F] Sodium Fluoride PET Kinetic Parameters in Bone Imaging.

Tanuj Puri, Michelle L Frost, Gary J Cook, Glen M Blake

Journal: Tomography (Ann Arbor, Mich.) 2022;7(4):843-854

PMID: 34941643

Abstract

This report describes the significance of the kinetic parameters (k-values) obtained from the analysis of dynamic positron emission tomography (PET) scans using the Hawkins model describing the pharmacokinetics of sodium fluoride ([F]NaF) to understand bone physiology. Dynamic [F]NaF PET scans may be useful as an imaging biomarker in early phase clinical trials of novel drugs in development by permitting early detection of treatment-response signals that may help avoid late-stage attrition.

Address: Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, UK.; Institute of Cancer Research Clinical Trials & Statistics Unit (ICR-CTSU), Institute of Cancer Research, Sutton SM2 5NG, UK.; Department of Cancer Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London SE1 7EH, UK.

DOI: 10.3390/tomography7040071

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MeSH Terms: Fluorine Radioisotopes, Positron-Emission Tomography, Sodium Fluoride