Therapeutic potential of indole alkaloids in respiratory diseases: A comprehensive review.

Rajib Das, Abu Montakim Tareq, Saikat Mitra, Kuldeep Dhama, Talha Bin Emran, Ali M Alqahtani, Firzan Nainu, Shajuthi Rahman Prova, Sifat Ara Sultana, Md Sahab Uddin, Jesus Simal-Gandara

Journal: Phytomedicine : international journal of phytotherapy and phytopharmacology 2021;90():153649

PMID: 34325978

Full Text on Elsevier Science View on PubMed

Abstract

BACKGROUND

Indole alkaloids are very promising for potential therapeutic purposes and appear to be particularly effective against respiratory diseases. Several experimental studies have been performed, both in vivo and in vitro, to evaluate the effectiveness of indole alkaloids for the management of respiratory disorders, including asthma, emphysema, tuberculosis, cancer, and pulmonary fibrosis.

PURPOSE

The fundamental objective of this review was to summarize the in-depth therapeutic potential of indole alkaloids against various respiratory disorders.

STUDY DESIGN

In addition to describing the therapeutic potential, this review also evaluates the toxicity of these alkaloids, which have been utilized for therapeutic benefits but have demonstrated toxic consequences. Some indole alkaloids, including scholaricine, 19-epischolaricine, vallesamine, and picrinine, which are derived from the plant Alstonia scholaris, have shown toxic effects in non-rodent models.

METHODS

This review also discusses clinical studies exploring the therapeutic efficacy of indole alkaloids, which have confirmed the promising benefits observed in vivo and in vitro.

RESULTS

The indole alkaloidal compounds have shown efficacy in subjects with respiratory diseases.

CONCLUSION

The available data established both preclinical and clinical studies confirm the potential of indole alkaloids to treat the respiratory disorders.

Address: Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka 1000, Bangladesh.; Faculty of Pharmacy, Hasanuddin University, Makassar, South Sulawesi 90245, Indonesia.; Department of Pharmacy, BGC Trust University Bangladesh, Chittagong 4381, Bangladesh. Electronic address: [email protected].; Department of Pharmacy, International Islamic University Chittagong, Chittagong 4318, Bangladesh.; Department of Pharmacy, Southeast University, Dhaka 1213, Bangladesh; Pharmakon Neuroscience Research Network, Dhaka 1207, Bangladesh.; Department of Pharmacology, College of Pharmacy, King Khalid University, Abha 62529, Saudi Arabia.; Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Bareilly 243122, Uttar Pradesh, India.; Nutrition and Bromatology Group, Department of Analytical and Food Chemistry, Faculty of Food Science and Technology, University of Vigo - Ourense Campus, E32004 Ourense, Spain. Electronic address: [email protected].

DOI: 10.1016/j.phymed.2021.153649

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MeSH Terms: Alstonia, Humans, Indole Alkaloids, Lung Diseases, Molecular Structure