Triple-helix polysaccharides: Formation mechanisms and analytical methods.

Xiaoyu Guo, Ji Kang, Zhiyuan Xu, Qingbin Guo, Lifeng Zhang, Haifeng Ning, Steve W Cui

Journal: Carbohydrate polymers 2021;262():117962

PMID: 33838830

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Abstract

Triple helix conformation of polysaccharides is generally believed to be associated with their biological activities. However, the formation mechanisms and analytical methods for the triple helix polysaccharides, to our best knowledge, have not been systematically investigated. This article reviews specifically the literature on the formation and characterization of triple-helix polysaccharides. The formation mechanisms and related structural-conformation-bioactivity relationships are discussed; various analytical methods for characterizing triple-helix polysaccharides are summarized. This review devotes to a better understanding of the formation of polysaccharides based triple-helix structure and related analytical methods. These could provide some insights and inspirations for their applications in both food and pharmaceutical industries.

Address: State Key Laboratory of Food Nutrition and Safety, School of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin, 300457, China.; State Key Laboratory of Dairy Biotechnology, Technology Center Bright Dairy & Food Co., Ltd, Shanghai, 200436, China.; State Key Laboratory of Food Nutrition and Safety, School of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin, 300457, China. Electronic address: [email protected].; Linyi Action Biotech Co., Ltd., Jinluo Sci. & Tech. Park, Lanshan, Linyi, Shandong, 276036, China.; Guelph Research and Development Centre, Agriculture and Agri-Food Canada, Guelph, ON, N1G 5C9, Canada.

DOI: 10.1016/j.carbpol.2021.117962

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MeSH Terms: Antioxidants, Coloring Agents, Congo Red, Immunomodulation, Models, Molecular, Molecular Conformation, Molecular Structure, Monosaccharides, Polysaccharides, Structure-Activity Relationship