Histone Deacetylase Inhibitors and Papillary Thyroid Cancer.

Eleftherios Spartalis, Konstantinos Kotrotsios, Dimosthenis Chrysikos, Michael Spartalis, Stavroula A Paschou, Dimitrios Schizas, Konstantinos Tsamakis, Dimitrios Dimitroulis, Theodore Troupis, Nikolaos Nikiteas

Journal: Current pharmaceutical design 2021;27(18):2199-2208

PMID: 33308111

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Abstract

BACKGROUND/AIM

Papillary Thyroid Cancer (PTC) is the most common type of endocrine malignancy. Although PTC has an excellent prognosis, the recurrent or metastatic disease could affect patients' survival. Recent studies show that Histone Deacetylase Inhibitors (HDACIs) might be promising anticancer agents against PTC. The aim of this review is to evaluate the role of HDACIs as an additional modality in PTC treatment and to depict the latest trends of current research on this field.

MATERIALS AND METHODS

This literature review was performed using the MEDLINE database. The search strategy included terms: "thyroid cancer", "papillary", "HDAC", "histone", and "deacetylase".

RESULTS

Agents, such as Suberoyl Anilide Hydroxamic Acid, Trichostatin A, Valproic Acid, Sodium butyrate, Panobinostat, Belinostat, Romidepsin, CUDC907 and N-Hydroxy-7-(2-naphthylthio)-Hepanomide have shown promising anti-cancer effects on PTC cell lines but fail to trigger a major response in clinical trials.

CONCLUSION

HDACIs have no significant effect as monotherapy against PTC, but further research needs to be conducted in order to investigate their potential effect when used as an additional modality.

Address: 2nd Department of Propaedeutic Surgery, National and Kapodistrian University of Athens, Medical School, Athens, Greece.; Department of Anatomy, National and Kapodistrian University of Athens, Medical School, Athens, Greece.; Laboratory of Experimental Surgery and Surgical Research "N.S. Christeas", National and Kapodistrian University of Athens, Medical School, Athens, Greece.; Division of Endocrinology and Diabetes, Aghia Sophia Hospital, National and Kapodistrian University of Athens, Medical School, Athens, Greece.; 1st Department of Surgery, National and Kapodistrian University of Athens, Athens, Greece.; Second Department of Psychiatry, National and Kapodistrian University of Athens, Medical School, Athens, Greece.

DOI: 10.2174/1381612826666201211112234

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MeSH Terms: Histone Deacetylase Inhibitors, Histones, Humans, Hydroxamic Acids, Panobinostat, Thyroid Cancer, Papillary, Thyroid Neoplasms