Tanshinones: An Update in the Medicinal Chemistry in Recent 5 Years.

Zhencheng Lai, Jixiao He, Changxin Zhou, Huajun Zhao, Sunliang Cui

Journal: Current medicinal chemistry 2021;28(14):2807-2827

PMID: 32436817

Abstract

Tanshinones are an important type of natural products isolated from Salvia miltiorrhiza Bunge with various bioactivities. Tanshinone IIa, cryptotanshinone and tanshinone I are three kinds of tanshinones which have been widely investigated. Particularly, sodium tanshinone IIa sulfonate is a water-soluble derivative of tanshinone IIa and it is used in clinical in China for treating cardiovascular diseases. In recent years, there are increasing interests in the investigation of tanshinones derivatives in various diseases. This article presents a review of the anti-atherosclerotic effects, cardioprotective effects, anticancer activities, antibacterial activities and antiviral activities of tanshinones and structural modification work in recent years.

Address: Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.; Institute of Modern Chinese Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.; College of Pharmaceutical Sciences, Zhejiang Chinese Medical University, Hangzhou, China.

DOI: 10.2174/0929867327666200521124850

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MeSH Terms: Abietanes, Chemistry, Pharmaceutical, China, Humans, Salvia miltiorrhiza