Biological and Pharmacological Effects of Gamma-oryzanol: An Updated Review of the Molecular Mechanisms.

Elham Ramazani, Maryam Akaberi, Seyed Ahmad Emami, Zahra Tayarani-Najaran

Journal: Current pharmaceutical design 2021;27(19):2299-2316

PMID: 33138751

Abstract

BACKGROUND

Gamma-oryzanol (γ-oryzanol) is one of the rice bran oil (RBO) compounds, known as a principal food source throughout the world. In recent numerous experimental studies, γ-oryzanol has been revealed to have several useful pharmacological properties, such as anti-oxidant, anti-inflammatory, anti-cancer, anti-diabetic, ameliorating unpleasant menopausal symptoms, cholesterol-lowering, improving plasma lipid pattern, etc. Methods: In this study, we reviewed the scientific literature published up until 2020, which has evaluated the biological and pharmacological activity of gamma-oryzanol. This review summarizes the published data found in PubMed, Science Direct, and Scopus.

RESULTS AND CONCLUSION

The present review attempts to summarize the most related articles about the pharmacological and therapeutic potential from recent studies on γ-oryzanol to gain insights into design further studies to achieve new evidence that confirm the observed effects.

Address: Medical Toxicology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.; Department of Pharmacognosy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.; Department of Traditional Pharmacy, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

DOI: 10.2174/1381612826666201102101428

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MeSH Terms: Antioxidants, Cholesterol, Humans, Phenylpropionates, Rice Bran Oil