Sepsis-Associated Encephalopathy: Insight into Injury and Pathogenesis.

Lina Zhao, Yanxia Gao, Shigong Guo, Xin Lu, Shiyuan Yu, Zeng Zheng Ge, Hua Dong Zhu, Yi Li

Journal: CNS & neurological disorders drug targets 2021;20(2):112-124

PMID: 33208082

Abstract

Sepsis-associated encephalopathy causes long-term health problems in patients with sepsis. This review explores the pathogenesis of sepsis-associated encephalopathy, including its effects on the blood-brain barrier, microglia activation, mitochondrial dysfunction, the inflammatory medium and neurotransmitters and its roles in amino acid balance disorders, hyperammonemia, and intestinal flora imbalance. Understanding the etiology of sepsis-associated encephalopathy may allow the development of adjunctive therapies targeting its underlying mechanism and help develop preventative strategies.

DOI: 10.2174/1871527319999201117122158

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MeSH Terms: Biological Transport, Blood-Brain Barrier, Humans, Macrophage Activation, Neurotransmitter Agents, Sepsis, Sepsis-Associated Encephalopathy