The Mechanistic Role of Thymoquinone in Parkinson's Disease: Focus on Neuroprotection in Pre-Clinical Studies.

Mohammad Najim Uddin, Mohammad I Hoq, Israt Jahan, Shafayet A Siddiqui, Chayan D Clinton, Mohammed Ibrahim, Mohammad S Islam, Mohammad Jakaria

Journal: Current molecular pharmacology 2022;14(6):1083-1092

PMID: 33402092

Full Text on Ingenta plc View on PubMed

Abstract

Thymoquinone (TQ) is one of the leading phytochemicals, which is abundantly found in Nigella sativa L. seeds. TQ exhibited various biological effects such as antioxidant, anti-inflammatory, antimicrobial, and anti-tumoral in several pre-clinical studies. Parkinson's disease (PD) is a long-term neurodegenerative disease with movement difficulties, and the common feature of neurodegeneration in PD patients is caused by dopaminergic neural damage in the substantia nigra pars compacta. The neuroprotective activity of TQ has been studied in various neurological disorders. TQ-mediated neuroprotection against PD is yet to be reported in a single frame; therefore, this review is intended to narrate the potentiality of TQ in the therapy of PD. TQ has been shown to protect against neurotoxins via amelioration of neuroinflammation, oxidative stress, and apoptosis, thereby protecting neurodegeneration in PD models. TQ could be an emerging therapeutic intervention in PD management, but mechanistic studies remain to be investigated to clarify its neuroprotective role.

Address: Department of Pharmacy, Faculty of Science & Engineering, International Islamic University Chittagong, Chattogram 4318,Bangladesh.; School of Public Health, Epidemiology and Social Medicine at the Institute of Medicine, University of Gothenburg, S-405 30, Gothenburg,Sweden.; Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali 3814,Bangladesh.; School of Chemical Engineering, Yeungnam University, Gyeongsan 38541,Korea.; Department of Pharmacy, Faculty of Science & Engineering, Southern University Bangladesh, Chittagong4000,Bangladesh.; Melbourne Dementia Research Centre, The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC3052,Australia.

DOI: 10.2174/1874467214666210105140944