Techniques, perspectives, and challenges of bioactive peptide generation: A comprehensive systematic review.

Meisam Barati, Fardin Javanmardi, Seyed Mohammad Hosein Mousavi Jazayeri, Masoumeh Jabbari, Jamal Rahmani, Farzaneh Barati, Hamid Nickho, Sayed Hossein Davoodi, Neda Roshanravan, Amin Mousavi Khaneghah

Journal: Comprehensive reviews in food science and food safety 2021;19(4):1488-1520

PMID: 33337080

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Abstract

Due to the digestible refractory and absorbable structures of bioactive peptides (BPs), they could induce notable biological impacts on the living organism. In this regard, the current study was devoted to providing an overview regarding the available methods for BPs generation by the aid of a systematic review conducted on the published articles up to April 2019. In this context, the PubMed and Scopus databases were screened to retrieve the related publications. According to the results, although the characterization of BPs mainly has been performed using enzymatic and microbial in-vitro methods, they cannot be considered as suitable techniques for further stimulation of digestion in the gastrointestinal tract. Therefore, new approaches for both in-vivo and in-silico methods for BPs identification should be developed to overcome the obstacles that belonged to the current methods. The purpose of this review was to compile the recent analytical methods applied for studying various aspects of food-derived biopeptides, and emphasizing generation at in vitro, in vivo, and in silico.

Address: Student Research Committee, Department of Cellular and Molecular Nutrition, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Department of Food Science and Technology, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Nutrition and Metabolic Disease Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.; Department of Community Nutrition, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Department of Biotechnology, Faculty of Biological Sciences, Alzahra University, Tehran, Iran.; Immunology Research Center, Iran University of Medical Sciences, Tehran, Iran.; Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.; Department of Clinical Nutrition and Dietetic, National Institute and Faculty of Nutrition and Food Technology; Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.; Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.; Department of Food Science, Faculty of Food Engineering, University of Campinas (UNICAMP), São Paulo, Brazil.

DOI: 10.1111/1541-4337.12578

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https://doi.org/10.1111/1541-4337.12578

MeSH Terms: Computer Simulation, Dietary Proteins, Digestion, Humans, In Vitro Techniques, Peptide Biosynthesis, Peptides, Proteome