Anti-inflammatory principles from Lindera aggregata.

Ping-Chung Kuo, Yi-Hung Wu, Hsin-Yi Hung, Sio-Hong Lam, Guo-Hao Ma, Liang-Mou Kuo, Tsong-Long Hwang, Daih-Huang Kuo, Tian-Shung Wu

Journal: Bioorganic & medicinal chemistry letters 2021;30(13):127224

PMID: 32359855

Full Text on Elsevier Science View on PubMed

Abstract

Four new sesquiterpenes (1-4), one new alkaloid (5), and one new benzenoid glycoside (6) were characterized from Lindera aggregata, and their structures were elucidated according to their spectrometric analytical data. Among these isolates, 3 and 4 were constructed as possessing unprecedented carbon skeletons from the natural source. Some of these purified constituents were examined for their anti-inflammatory bioactivity. Among the tested compounds, linderaggredin C (3), (+)-N-methyllaurotetanine, and (+)-isoboldine displayed the significant inhibition of superoxide anion generation in human neutrophils with IC values of 7.45 ± 0.74, 8.36 ± 0.11, and 5.81 ± 0.59 μM, respectively.

Address: School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.; Hsinhua Forest Station, The Experimental Forest Management Office, National Chung-Hsing University, Taichung 402, Taiwan.; Department of Chemistry, National Cheng Kung University, Tainan 701, Taiwan.; Department of General Surgery, Chang Gung Memorial Hospital at Chiayi, Chiayi 613, Taiwan; School of Medicine, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.; Graduate Institute of Natural Products, College of Medicine, Chinese Herbal Medicine Research Team, Healthy Aging Research Center, Chang Gung University, Taoyuan 333, Taiwan; Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan; Research Center for Chinese Herbal Medicine, Research Center for Industry of Human Ecology, Graduate Institute of Health Industry Technology, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan.; Department of Pharmacy, College of Pharmacy and Health Care, Tajen University, Pingtung 907, Taiwan.; School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan; Department of Pharmacy, College of Pharmacy and Health Care, Tajen University, Pingtung 907, Taiwan. Electronic address: [email protected].

DOI: 10.1016/j.bmcl.2020.127224

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MeSH Terms: Anti-Inflammatory Agents, Humans, Lindera, Molecular Structure, Neutrophils, Pancreatic Elastase, Sesquiterpenes, Superoxides