Iron, Myelin, and the Brain: Neuroimaging Meets Neurobiology.

Harald E Möller, Lucia Bossoni, James R Connor, Robert R Crichton, Mark D Does, Roberta J Ward, Luigi Zecca, Fabio A Zucca, Itamar Ronen

Journal: Trends in neurosciences 2020;42(6):384-401

PMID: 31047721

Full Text on Elsevier Science View on PubMed

Abstract

Although iron is crucial for neuronal functioning, many aspects of cerebral iron biology await clarification. The ability to quantify specific iron forms in the living brain would open new avenues for diagnosis, therapeutic monitoring, and understanding pathogenesis of diseases. A modality that allows assessment of brain tissue composition in vivo, in particular of iron deposits or myelin content on a submillimeter spatial scale, is magnetic resonance imaging (MRI). Multimodal strategies combining MRI with complementary analytical techniques ex vivo have emerged, which may lead to improved specificity. Interdisciplinary collaborations will be key to advance beyond simple correlative analyses in the biological interpretation of MRI data and to gain deeper insights into key factors leading to iron accumulation and/or redistribution associated with neurodegeneration.

Address: Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstr. 1A, Leipzig, Germany. Electronic address: [email protected].; Department of Radiology, C.J. Gorter Center for High Field MRI, Leiden University Medical Center, Leiden, The Netherlands.; Department of Neurosurgery, Pennsylvania State University College of Medicine, Hershey, PA, USA.; Université Catholique de Louvain, Louvain-la-Neuve, Belgium.; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.; Centre for Neuroinflammation and Neurodegeneration, Department of Medicine, Hammersmith Hospital Campus, Imperial College London, London, UK.; Institute of Biomedical Technologies, National Research Council of Italy, Segrate, Milan, Italy; Department of Psychiatry, Columbia University Medical Center, New York State Psychiatric Institute, New York, NY, USA.; Institute of Biomedical Technologies, National Research Council of Italy, Segrate, Milan, Italy.

DOI: 10.1016/j.tins.2019.03.009

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MeSH Terms: Brain, Brain Chemistry, Humans, Iron, Myelin Sheath, Neurobiology, Neuroimaging