Pharmacognosy in the digital era: shifting to contextualized metabolomics.

Pierre-Marie Allard, Jonathan Bisson, Antonio Azzollini, Guido F Pauli, Geoffrey A Cordell, Jean-Luc Wolfender

Journal: Current opinion in biotechnology 2019;54():57-64

PMID: 29499476

Abstract

Humans have co-evolved alongside numerous other organisms, some having a profound effect on health and nutrition. As the earliest pharmaceutical subject, pharmacognosy has evolved into a meta-discipline devoted to natural biomedical agents and their functional properties. While the acquisition of expanding data volumes is ongoing, contextualization is lagging. Thus, we assert that the establishment of an integrated and open databases ecosystem will nurture the discipline. After proposing an epistemological framework of knowledge acquisition in pharmacognosy, this study focuses on recent computational and analytical approaches. It then elaborates on the flux of research data, where good practices could foster the implementation of more integrated systems, which will in turn help shaping the future of pharmacognosy and determine its constitutional societal relevance.

Copyright © 2018 Elsevier Ltd. All rights reserved.

Address: School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Rue Michel-Servet 1, CH-1211 Geneva 4, Switzerland. Electronic address: [email protected].; Center for Natural Product Technologies, Program for Collaborative Research in the Pharmaceutical Sciences (PCRPS), and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 833 South Wood Street, Chicago, IL 60612, United States.; School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Rue Michel-Servet 1, CH-1211 Geneva 4, Switzerland.; Natural Products Inc., Evanston, IL 60203, United States; Department of Pharmaceutics, College of Pharmacy, University of Florida, Gainesville, FL 32610, United States.
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