HER2 testing in gastric cancer: results of a German expert meeting.

Florian Lordick, Salah-Eddin Al-Batran, Manfred Dietel, Timo Gaiser, Ralf-Dieter Hofheinz, Thomas Kirchner, Hans H Kreipe, Sylvie Lorenzen, Markus Möhler, Alexander Quaas, Christoph Röcken, Josef Rüschoff, Andrea Tannapfel, Peter Thuss-Patience, Gustavo Baretton

Journal: Journal of cancer research and clinical oncology 2017;143(5):835-841

PMID: 28285403

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Abstract

Valid HER2 testing is essential for optimal therapy of patients with HER2-positive gastric cancer and the correct use of first-line chemotherapy. While testing for HER2 status in breast cancer is routinely performed, this is not the case for HER2 testing in gastric cancer and it is usually only performed on clinician request. An interdisciplinary German expert group (pathologists and clinicians) took the challenges of HER2 testing in gastric cancer as an opportunity to address essential aspects and questions for the practical use of HER2 testing in this indication. The recommendations made in this manuscript reflect the consensus of all participants and reflect their opinions and long-term experience in this field.

Address: Universitätsklinikum Leipzig, Universitäres Krebszentrum (UCCL), Liebigstraße 20, 04103, Leipzig, Germany. [email protected].; UCT University Cancer Center Frankfurt, Frankfurt am Main, Germany.; Institut für Pathologie, Charité Universitätsmedizin Berlin Campus Mitte, Berlin, Germany.; Pathologisches Institut der Universitätsmedizin Mannheim, Mannheim, Germany.; Universitätsmedizin Mannheim, Mannheim, Germany.; Pathologisches Institut der Ludwig-Maximilians-Universität München, Munich, Germany.; Institut für Pathologie, Medizinische Hochschule Hannover, Hanover, Germany.; Medizinische Klinik des Klinikums rechts der Isar, Munich, Germany.; Medizinische Klinik und Poliklinik, Universitätsmedizin Mainz, Mainz, Germany.; Institut für Pathologie, Uniklinik Köln, Cologne, Germany.; Institut für Pathologie Christian-Albrechts-Universität, Kiel, Germany.; Institut für Pathologie Nordhessen u. Targos GmbH, Kassel, Germany.; Georgius Agricola Stiftung Ruhr, Institut für Pathologie der Ruhr-Universität Bochum am Berufsgenossenschaftlichen Universitätsklinikum, Bochum, Germany.; Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum, Berlin, Germany.; Institut für Pathologie, Universitätsklinikum Carl Gustav Carus, Dresden, Germany.

DOI: 10.1007/s00432-017-2374-x