Emerging Human Fetuin A Assays for Biomedical Diagnostics.

Sandeep Kumar Vashist, E Marion Schneider, A G Venkatesh, John H T Luong

Journal: Trends in biotechnology 2018;35(5):407-421

PMID: 28094081

Full Text on Elsevier Science View on PubMed

Abstract

Human fetuin A (HFA) plays a prominent pathophysiological role in numerous diseases and pathophysiological conditions with considerable biomedical significance; one example is the formation of calciprotein particles in osteoporosis and impaired calcium metabolisms. With impressive advances in in vitro diagnostic assays during the last decade, ELISAs have become a workhorse in routine clinical diagnostics. Recent diagnostic formats involve high-sensitivity immunoassay procedures, surface plasmon resonance, rapid immunoassay chemistries, signal enhancement, and smartphone detection. The current trend is toward fully integrated lab-on-chip platforms with smartphone readouts, enabling health-care practitioners and even patients to monitor pathological changes in biomarker levels. This review provides a critical analysis of advances made in HFA assays along with the challenges and future prospects.

Address: Immunodiagnostic Systems, Rue Ernest Solvay 101, 4000 Liege, Belgium. Electronic address: [email protected].; Sektion Experimentelle Anaesthesiologie, University Hospital Ulm, Albert Einstein Allee 23, 89081 Ulm, Germany.; Roswell Biotechnologies Inc, 11558 Sorrento Valley Road, Suite Number 4, San Diego, CA 92121, USA.; Innovative Chromatography Group, Irish Separation Science Cluster (ISSC), Department of Chemistry and Analytical, Biological Chemistry Research Facility (ABCRF), University College Cork, Cork, Ireland.

DOI: 10.1016/j.tibtech.2016.12.006

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MeSH Terms: Biomarkers, Biosensing Techniques, Blood Chemical Analysis, Conductometry, Disposable Equipment, Humans, Immunoassay, Mobile Applications, Point-of-Care Testing, Smartphone, Surface Plasmon Resonance, alpha-2-HS-Glycoprotein